{"id":19058,"date":"2024-07-16T14:31:26","date_gmt":"2024-07-16T18:31:26","guid":{"rendered":"https:\/\/foodmedcenter.org\/?p=19058"},"modified":"2024-07-16T14:31:28","modified_gmt":"2024-07-16T18:31:28","slug":"study-spotlight-take-away-with-chef-dr-mike-salt-the-heart","status":"publish","type":"post","link":"https:\/\/foodmedcenter.org\/es_do\/study-spotlight-take-away-with-chef-dr-mike-salt-the-heart\/","title":{"rendered":"Study Spotlight Take-Away with Chef Dr. Mike: Salt &amp; The Heart"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u201cThere must be something strangely sacred in salt. It is in our tears and in the sea.\u201d<\/p>\n<cite>\u2015 Khalil Gibran<\/cite><\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">As cardiologists, one of the fundamental and immutable laws we were taught was that no patients required and benefited more from salt restriction than those with congestive heart failure (CHF). One of the hallmarks of CHF is changes to the neurohumoral system that lead to fluid retention, manifesting as edema in the peripheral extremities and shortness of breath due to fluid accumulation in the lungs. Sodium (salt) restriction was a cornerstone of treatment for decades.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Such dietary guidelines were extended beyond this perceived most vulnerable population to include not only those with hypertension (roughly 120 million in the US or about 47% of the adult population<a href=\"#_ftn1\" id=\"_ftnref1\">[1]<\/a>) but to the general public at large. Servicing this market, with a compound annual growth rate (CAGR) estimated at approximately 5% due to a continued emphasis on alleged health benefits, is big business, with a market worth around $7.5 billion worldwide in 2020.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">And yet, for such a big investment, there is precious little data documenting positive outcomes from such an intervention, especially as the American Heart Association currently recommends no more than 1.5 g per day, and the World Health Organization recommends no more than 2 g of per day. These recommendations are driven in no small way by influential trials like the DASH-Sodium trial and others promoting a low-sodium dietary approach. However, other experts have countered that such recommendations are based \u201con the premise that reductions in sodium intake, irrespective of the levels, will lower blood pressure, and, in turn, reduce cardiovascular disease occurrence. These guidelines have been developed without effective interventions to achieve sustained low sodium intake in free-living individuals, without a feasible method to estimate sodium intake reliably in individuals, and without high-quality evidence that low sodium intake reduces cardiovascular events (compared with moderate intake)<a id=\"_ftnref2\" href=\"#_ftn2\">[2]<\/a>\u201d and that less restrictive guidelines, i.e., less than 5 g per day, are more reasonable. Currently, the average sodium consumption worldwide is between 2.3-4.6 g per day (1-2 teaspoons of salt).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This current review sought to examine the evidence behind recommending dietary sodium restriction in an extremely high-risk population consisting of those with congestive heart failure.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1111\/eci.14265\">The Study:<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The review examined the data available regarding dietary sodium restriction and outcomes in people suffering from congestive heart failure.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><em>The Take-Away:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The composite data suggest a J-shaped curve with both cardiovascular and all-cause mortality rising when sodium intake is greater than 5 g per day or less than 2 g per day.<\/li>\n\n\n\n<li>Multiple studies also agreed that a \u201cstrict reduction in sodium intake is not sustainable and therefore not recommendable. Hence, in the absence of reliable methods to assess intake and the difficulty of maintaining a low intake, it becomes impossible for the general public and patients to know exactly how much sodium they are ingesting and adhere to strict recommendations<em>.<\/em>\u201d<\/li>\n\n\n\n<li>There is <strong>no<\/strong> randomized clinical trial evidence that reducing sodium intake to less than 2 g per day leads to a reduction in cardiovascular events in the general population; such benefits are based on modeling \u201cthe probable drop in event rates induced by a sustained reduction in blood pressure of the same magnitude as that shown in the DASH-sodium or similar trials.\u201d<\/li>\n\n\n\n<li>The initial blood pressure reduction seen with sodium restriction attenuates over time, likely secondary to physiologic compensatory mechanisms.<\/li>\n\n\n\n<li>A Cochrane analysis (considered by many to be the gold standard) concluded that there was either no effect on mortality from sodium reduction or the effect was so small \u201cthat there was insufficient power to show an effect on mortality.\u201d<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><em>The Caveat:<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This study examined the role of sodium and fluid restriction in those suffering from congestive heart failure. A consideration in this discussion is the impact on the quality of life. A small study showed no benefit in preventing hospital readmission or reducing mortality with sodium restriction. However, there was a significant reduction in the quality of life reported by those in the intervention (low-sodium diet) arm. In asking people to make such lifestyle changes, we should be able to provide evidence of positive impacts in reducing morbidity and mortality. A meta-analysis of the many small trials conducted from 2000 to 2021 showed no reduction in preventing people from hospital admissions or any reduction in mortality.<a href=\"#_ftn3\" id=\"_ftnref3\">[3]<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The large SODIUM-HF trial published in <em>The Lancet<\/em> in 2022 added some clarity. It involved 26 centers in six countries and randomized 841 ambulatory congestive heart failure patients to less than 1.5 g of sodium per day or a more liberal regimen. The intervention period was 12 months, followed by another 12 months of follow-up. The conclusion was that sodium restriction did not reduce the composite outcome of all-cause mortality, cardiovascular hospitalization, or cardiovascular-related emergency department visits; in other words, \u201ca dietary intervention to reduce sodium intake did not reduce clinical events.\u201d<a href=\"#_ftn4\" id=\"_ftnref4\">[4]<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">One of the other important variables in this conversation is that often in terms of diet, isolated sodium reduction does not occur. For example, the DASH diet promotes increased consumption of vegetables and fruits along with decreasing sodium intake. As vegetables and fruits are powerful sources of potassium, this increases dietary potassium (which is known to reduce blood pressure) and changes the dietary sodium-potassium ratio. In fact, there is evidence from other investigations that suggests that the sodium-to-potassium ratio is more important and more predictive of morbidity and mortality than absolute sodium consumption.<a href=\"#_ftn5\" id=\"_ftnref5\">[5]<\/a> The review concludes that \u201cAll patients with heart failure should favour fresh fruits and vegetables, and preferably prepare their own meals, rather than eating prepared meals that typically contain large amounts of sodium [e.g., ultra-processed foods].\u201d This seems to be sage advice for everyone.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"#_ftnref1\" id=\"_ftn1\">[1]<\/a> (AHA, 2024)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"#_ftnref2\" id=\"_ftn2\">[2]<\/a> (O\u2019Donnell, 2020)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"#_ftnref3\" id=\"_ftn3\">[3]<\/a> (Colin-Ramirez, 2023)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"#_ftnref4\" id=\"_ftn4\">[4]<\/a> (Ezekowitz, 2022)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"#_ftnref5\" id=\"_ftn5\">[5]<\/a> (Mente, 2014)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">The Study:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1111\/eci.14265\">Raggi P. Salt versus no salt restriction in heart failure a review. Eur J Clin Invest. 2024; 00:e14265. doi:10.1111\/eci.14265<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Additional resources:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25519688\/\">Adler AJ, Taylor F, Martin N, Gottlieb S, Taylor RS, Ebrahim S. Reduced dietary salt for the prevention of cardiovascular disease. Cochrane Database Syst Rev. 2014;(12):CD009217. DOI: 10.1002\/14651858.CD009217.pub3.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"American%20Heart%20Association.%20Hypertension%20and%20Physical%20Activity%202024%20statistics%20infographic.%20(2024).%20Https:\/newsroom.heart.org\/file\/hypertension-and-physical-activity-2024-statistics-infographic?action=%0d\">American Heart Association. Hypertension and Physical Activity 2024 statistics infographic. (2024). Https:\/\/newsroom.heart.org\/file\/hypertension-and-physical-activity-2024-statistics-infographic?action=<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.heart.org\/en\/healthy-living\/healthy-eating\/eat-smart\/sodium\/how-much-sodium-should-i-eat-per-day\">American Heart Association. How much sodium should I eat per day? (2024). https:\/\/www.heart.org\/en\/healthy-living\/healthy-eating\/eat-smart\/sodium\/how-much-sodium-should-i-eat-per-day<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36373551\/\">Colin-Ramirez E, Sepehrvand N, Rathwell S, Ross H, Escobedo J, Macdonald P, Troughton R, Saldarriaga C, Lanas F, Doughty R, McAlister FA, Ezekowitz JA.Sodium restriction in patients with heart failure: a systematic review and meta-analysis of randomized clinical trials. Circ Heart Fail. 2023;16(1): e009879. doi: 10.1161\/CIRCHEARTFAILURE.122.009879.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35381194\/\">Ezekowitz JA, Colin-Ramirez E, Ross H, Escobedo J, Macdonald P, Troughton R, Saldarriaga C, Alemayehu W, McAlister FA, Arcand J, Atherton J, Doughty R, Gupta M, Howlett J, Jaffer S, Lavoie A, Lund M, Marwick T, McKelvie R, Moe G, Pandey AS, Porepa L, Rajda M, Rheault H, Singh J, Toma M, Virani S, Zieroth S; SODIUM-HF Investigators. Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial. Lancet. 2022;399(10333):1391-1400. doi:10.1016\/S0140-6736(22)00369-5.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24651634\/\">Graudal N, J\u00fcrgens G, Baslund B, Alderman MH. Compared with usual sodium intake, low-and excessive-sodium diets are associated with increased mortality: a meta-analysis. Am J Hypertens. 2014; 27:1129-1137.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37895150\/\">Manolis AA, Manolis TA, Manolis AS. Neurohumoral activation in heart failure. Int J Mol Sci. 2023; 24:15472. DOI: 10.3390\/ijms242015472.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1311989\">Mente A, O&#8217;Donnell MJ, Rangarajan S, et al. Association of urinary sodium and potassium excretion with blood pressure. N Engl J Med. 2014; 371: 601-661. DOI:10.1056\/NEJMoa1311989.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27216139\/\">Mente A, O&#8217;Donnell M, Rangarajan S, Dagenais G, Lear S, McQueen M, Diaz R, Avezum A, Lopez-Jaramillo P, Lanas F, Li W, Lu Y, Yi S, Rensheng L, Iqbal R, Mony P, Yusuf R, Yusoff K, Szuba A, Oguz A, Rosengren A, Bahonar A, Yusufali A, Schutte AE, Chifamba J, Mann JF, Anand SS, Teo K, Yusuf S; PURE, EPIDREAM and ONTARGET\/TRANSCEND Investigators. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016; 388(10043):465-475.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33011774\/\">O&#8217;Donnell M, Mente A, Alderman MH, Brady AJB, Diaz R, Gupta R, L\u00f3pez-Jaramillo P, Luft FC, L\u00fcscher TF, Mancia G, Mann JFE, McCarron D, McKee M, Messerli FH, Moore LL, Narula J, Oparil S, Packer M, Prabhakaran D, Schutte A, Sliwa K, Staessen JA, Yancy C, Yusuf S. Salt and cardiovascular disease: insufficient evidence to recommend low sodium intake. Eur Heart J. 2020. 41(35):3363-3373. doi:10.1093\/eurheartj\/ehaa586.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11136953\/\">Sacks FM, Svetkey LP, Vollmer WM, Appel LJ, Bray GA, Harsha D, Obarzanek E, Conlin PR, Miller ER 3rd, Simons-Morton DG, Karanja N, Lin PH; DASH-Sodium Collaborative Research Group. Effects on blood pressure of reduced dietary sodium and the dietary approaches to stop hypertension (DASH) diet. DASH-sodium Collaborative Research Group. N Engl J Med. 2001; 344:3-10. DOI:10.1056\/NEJM200101043440101.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.who.int\/publications\/i\/item\/9789241504836\">World Health Organization. Guideline: sodium intake for adults and children. (2024). https:\/\/www.who.int\/publications\/i\/item\/9789241504836<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cThere must be something strangely sacred in salt. It is in our tears and in the sea.\u201d \u2015 Khalil Gibran As cardiologists, one of the fundamental and immutable laws we&hellip;<\/p>","protected":false},"author":56,"featured_media":19059,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[11374,786,11367,11368,191],"tags":[11722,183,195,11723,11571,650,11724,402,403,273],"class_list":["post-19058","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-culinary-medicine-and-culinary-nutrition","category-featured","category-food-as-treatment-for-disease","category-food-for-preventive-care","category-healthy-living","tag-congestive-heart-failure","tag-diet","tag-health","tag-heart-failure","tag-hypertension","tag-low-sodium","tag-low-sodium-diet-2","tag-salt","tag-sodium","tag-vegetables"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.9 (Yoast SEO v27.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Study Spotlight Take-Away with Chef Dr. Mike: Salt &amp; The Heart &#8212;<\/title>\n<meta name=\"description\" content=\"Discover the impact of salt (sodium) on heart health and the connection between salt restriction and congestive heart failure treatment.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/foodmedcenter.org\/es_do\/study-spotlight-take-away-with-chef-dr-mike-salt-the-heart\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study Spotlight Take-Away with Chef Dr. Mike: Salt &amp; The Heart\" \/>\n<meta property=\"og:description\" content=\"Discover the impact of salt (sodium) on heart health and the connection between salt restriction and congestive heart failure treatment.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/foodmedcenter.org\/es_do\/study-spotlight-take-away-with-chef-dr-mike-salt-the-heart\/\" \/>\n<meta property=\"og:site_name\" content=\"Center For Food As Medicine &amp; Longevity\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/foodmedcenter\" \/>\n<meta property=\"article:author\" content=\"chefdrmike\" \/>\n<meta property=\"article:published_time\" content=\"2024-07-16T18:31:26+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-16T18:31:28+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/foodmedcenter.org\/wp-content\/uploads\/mix-in-grn1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2048\" \/>\n\t<meta property=\"og:image:height\" content=\"1365\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Michael S. 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He holds cross-faculty appointments at The University of Montana (College of Health and UM Medicine, School of Public Health, and\u00a0Missoula College Culinary Arts Program).\u00a0He currently teaches one of the country\u2019s leading courses on Culinary Medicine at The University of Montana. 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