{"id":19242,"date":"2024-11-11T13:30:34","date_gmt":"2024-11-11T18:30:34","guid":{"rendered":"https:\/\/foodmedcenter.org\/?p=19242"},"modified":"2024-11-12T07:15:17","modified_gmt":"2024-11-12T12:15:17","slug":"study-spotlight-take-away-with-chef-dr-mike-the-brain-gut-alzheimers","status":"publish","type":"post","link":"https:\/\/foodmedcenter.org\/es_do\/study-spotlight-take-away-with-chef-dr-mike-the-brain-gut-alzheimers\/","title":{"rendered":"Study Spotlight Take-Away with Chef Dr. Mike: The Brain, Gut &amp; Alzheimer\u2019s"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u201c<em>A healthy gut is essential for a healthy mind.\u201d<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">~ <em>Emeran Mayer<\/em><\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">Over the last several years, there has been increasing evidence implicating the gut-brain axis in the etiology of neurodegenerative conditions like Alzheimer\u2019s disease. Previous studies utilizing animal models have demonstrated the development of neurodegenerative conditions following the transplantation of the gut microbiome from an affected animal to a previously healthy one, suggesting a strong link between the gastrointestinal tract and the brain.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This week\u2019s study looks at the association between the level of gut inflammation and the spectrum of degenerative neural cognition in Alzheimer\u2019s-type dementia (AD). The human participants were divided into those with clinical AD and those who remain cognitively unimpaired (CU). The latter group was further subdivided into those who had no evidence of amyloid pathology (a diagnostic marker associated with increased risk of developing AD) designated CU A\u03b2\u2212, and those who were cognitively unimpaired but were at an increased risk of developing Alzheimer\u2019s-type dementia in the future due to the presence of amyloid pathology, designated CU A\u03b2+.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.nature.com\/articles\/s41598-023-45929-z#Abs1\">The Study:<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The study assessed fecal samples from older adults.<\/li>\n\n\n\n<li>Samples were obtained from 125 individuals who participated in two prior Alzheimer&#8217;s prevention studies.<\/li>\n\n\n\n<li>The samples were measured for calprotectin, an established marker of intestinal inflammation.<\/li>\n\n\n\n<li>Elevated calprotectin levels are seen in diseases where there is a compromise of the integrity of the normal gut barrier.<\/li>\n\n\n\n<li>Calprotectin levels were correlated with clinical diagnosis, participant age, cerebrospinal fluid biomarkers of AD pathology, amyloid burden (measured using 11C-Pittsburgh compound B positron emission tomography (PiB PET)) and performance on cognitive tests measuring executive function and verbal learning and recall.<\/li>\n\n\n\n<li>Calprotectin levels correlated with increasing age.<\/li>\n\n\n\n<li>Calprotectin levels were highest in those with amyloid-confirmed Alzheimer\u2019s-type dementia.<\/li>\n\n\n\n<li>Among those participants with AD, higher calprotectin levels correlated to a greater amyloid burden.<\/li>\n\n\n\n<li>Among the participants who were cognitively unimpaired (CU), \u201ccalprotectin levels were also associated with cerebrospinal fluid markers of AD, and with lower verbal memory function (CU A\u03b2+) \u2026. Taken together, these findings suggest that intestinal inflammation is linked with brain pathology even in the earliest disease stages. Moreover, intestinal inflammation may exacerbate the progression toward AD.\u201d<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><em>The Caveat:<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">One of the possible mechanisms by which age-related neurodegenerative diseases like Alzheimer\u2019s-type dementia (AD) arise may be related to a form of inflammation known as \u201cinflammaging.\u201d Inflammaging is chronic, continuous, low-grade inflammation associated with age, which may be driven by alterations in the composition of the gut microbiome and by a reduced selectivity of the intestinal barrier. A possible cause of this inflammation may be linked to age-related shifts in the composition of the gut microbiota with the subsequent production of an inflammatory environment that causes degradation of the epithelial barrier. The result is that bacterial components that normally remain in the lumen of the gut instead enter the bloodstream and cause inflammatory havoc, like a black Friday mob of shoppers at the opening of Walmart.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Such a \u201cleaky gut\u201d is also associated with other inflammatory conditions like irritable bowel disease and type II diabetes (T2DM). One of the challenges of deciphering such an association is the chicken and the egg problem: does a \u201cleaky gut\u201d <em>cause <\/em>diseases like AD and T2DM, or is a \u201cleaky gut\u201d a consequence of having these conditions? It is about remembering that correlation is not necessarily causation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the current study, the presence of AD was defined by cerebral aggregation of amyloid beta (A\u03b2) and phosphorylated tau (pTau) proteins, accompanied by microglial and astrocytic activation and associated neuroinflammation. The study&#8217;s findings also suggested that \u201cage increases gut inflammation independently of symptomatic AD.\u201d However, increased gut inflammation was found in those participants who were cognitively unimpaired but amyloid-beta positive (A\u03b2+). This group scored lowest on memory function, suggesting a preclinical presentation or increased risk of developing AD in the future. The highest level of gut inflammation was found in those with clinical AD.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">An important caveat in this study is that although increasing levels of gut inflammation correlated to increasing risk and development of Alzheimer\u2019s-type dementia, the current research \u201ccannot rule out the possibility that development of AD pathology may exacerbate intestinal inflammation.\u201d With that being said, the researchers put forth a hypothesis that it is the increased gut microbiome inflammation that initiates a chronic, continuous, low-level systemic inflammation. This, slowly over time, causes incremental damage, which potentially leads to chronic diseases like diabetes, cardiovascular disease, and neurodegenerative conditions like AD.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The researchers are moving forward to test this hypothesis using a mouse model to see if diet changes associated with increased inflammation can trigger the rodent version of AD. If the forthcoming data suggests that that hypothesis is correct, this opens the door to dietary \u201cinterventions that mitigate intestinal inflammation [and] could have a beneficial impact on cognitive function in older adults.\u201d Now, that is, indeed, food for thought!<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-a-request-from-chef-dr-mike\">A Request from Chef Dr. Mike<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This week, I am asking a favor: If you enjoy and find the information here and articles like this weekly column at The Center for Food as Medicine helpful, I\u2019ve been nominated to potentially work with RFK Jr. as we share a focus on UPFs. One of the ways they are evaluating potential contributors is through a public voting process. If you know anyone who might help in supporting my efforts and could forward this to help generate a vote for my position, I would appreciate it. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1. If you\u2019d like to see more on my position on ultra-processed foods, please visit my TEDx talk at: <a href=\"https:\/\/t.co\/GqfEoDY4M6\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/youtube.com\/watch?v=8JBCNFOOSRM\u2026<\/a> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2. Please go to the website: <a href=\"https:\/\/t.co\/4TnmIWpIFY\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/nominees.mahanow.org\/t\/dr-michael-fenster\/11526<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3. Click on the \u201cvote\u201d button. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">4. If you already have an account and have signed in, this is all you need to do (thank you!). <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">5. If you do not already have an account, it will ask you to create one which involves: <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">a. Entering your name <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">b. Entering your email <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">c. Entering your ZIP Code. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">6. When your account is created, please hit the \u201cvote\u201d button on the page. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">7. Thank you!<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">The Study:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.nature.com\/articles\/s41598-023-45929-z#Abs1\">Heston, M.B., Hanslik, K.L., Zarbock, K.R. et al. Gut inflammation associated with age and Alzheimer\u2019s disease pathology: a human cohort study. Sci Rep 13, 18924 (2023). https:\/\/doi.org\/10.1038\/s41598-023-45929-z<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Additional resources:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30065258\/\">Ferrucci, L. &amp; Fabbri, E. Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty. Nat. Rev. Cardiol.15(9), 505\u2013522 (2018).<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29163474\/\">Fransen, F. et al. Aged gut microbiota contributes to systemical inflammaging after transfer to germ-free mice. Front. Immunol. 8,1385 (2017).<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25948052\/\">Man, A. L. et al. Age-associated modifications of intestinal permeability and innate immunity in human small intestine. Clin. Sci.129(7), 515\u2013527 (2015).<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28407483\/\">Thevaranjan, N. et al. Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction. Cell Host Microb. 21(4), 455-466.e4 (2017).<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4001874\/\">Valentini, L. et al. Small intestinal permeability in older adults. Physiol. Rep. 2(4), e00281 (2014).<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.nature.com\/articles\/s41598-019-57106-2\">Wilms, E. et al. Intestinal barrier function is maintained with aging: A comprehensive study in healthy subjects and irritable bowel syndrome patients. Sci. Rep. 10(1), 475 (2020).<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cA healthy gut is essential for a healthy mind.\u201d ~ Emeran Mayer Over the last several years, there has been increasing evidence implicating the gut-brain axis in the etiology of&hellip;<\/p>","protected":false},"author":56,"featured_media":19241,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[11374,786,11370,11367,11368,191],"tags":[11643,11710,183,11450,11622,11623,11720,221,11730],"class_list":["post-19242","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-culinary-medicine-and-culinary-nutrition","category-featured","category-food-as-medicine-and-policy","category-food-as-treatment-for-disease","category-food-for-preventive-care","category-healthy-living","tag-alzheimers-disease","tag-brain-gut-axis","tag-diet","tag-diet-related-disease","tag-gut-health","tag-gut-microbiome","tag-gut-microbiota","tag-healthy-eating","tag-neurodegenerative-disease"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.9 (Yoast SEO v27.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Exploring Alzheimer&#039;s Type Dementia: The Gut-Brain Connection &#8212;<\/title>\n<meta name=\"description\" content=\"What is the connection between gut inflammation, the gut-brain axis, and neurodegenerative diseases like Alzheimer&#039;s-type dementia?\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/foodmedcenter.org\/es_do\/study-spotlight-take-away-with-chef-dr-mike-the-brain-gut-alzheimers\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study Spotlight Take-Away with Chef Dr. Mike: The Brain, Gut &amp; Alzheimer\u2019s\" \/>\n<meta property=\"og:description\" content=\"What is the connection between gut inflammation, the gut-brain axis, and neurodegenerative diseases like Alzheimer&#039;s-type dementia?\" \/>\n<meta property=\"og:url\" content=\"https:\/\/foodmedcenter.org\/es_do\/study-spotlight-take-away-with-chef-dr-mike-the-brain-gut-alzheimers\/\" \/>\n<meta property=\"og:site_name\" content=\"Center For Food As Medicine &amp; Longevity\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/foodmedcenter\" \/>\n<meta property=\"article:author\" content=\"chefdrmike\" \/>\n<meta property=\"article:published_time\" content=\"2024-11-11T18:30:34+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-12T12:15:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/foodmedcenter.org\/wp-content\/uploads\/Gut-microbiome-barrier-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Michael S. 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