{"id":32083,"date":"2026-04-19T10:58:23","date_gmt":"2026-04-19T14:58:23","guid":{"rendered":"https:\/\/foodmedcenter.org\/vitality-male-infertility-and-diet\/"},"modified":"2026-04-19T10:58:23","modified_gmt":"2026-04-19T14:58:23","slug":"vitality-male-infertility-and-diet","status":"publish","type":"post","link":"https:\/\/foodmedcenter.org\/es_do\/vitality-male-infertility-and-diet\/","title":{"rendered":"Vitality: Male Infertility and Diet"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Report Author: Simran Sharma<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Report Date: March 3, 2025<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Table of Contents<\/h2>\n\n\n\n<nav id=\"TOC\" role=\"doc-toc\">\n<ul>\n<li><a href=\"#introduction\" id=\"toc-introduction\">Introduction<\/a><\/li>\n<li><a href=\"#significance-of-the-topic\" id=\"toc-significance-of-the-topic\">Significance of the Topic<\/a><\/li>\n<li><a href=\"#potential-cause-of-male-infertility\" id=\"toc-potential-cause-of-male-infertility\">Potential Cause of Male Infertility<\/a>\n<ul>\n<li><a href=\"#hormonal-imbalance\" id=\"toc-hormonal-imbalance\">Hormonal Imbalance<\/a><\/li>\n<li><a href=\"#sperm-quality-issue\" id=\"toc-sperm-quality-issue\">Sperm Quality Issue<\/a><\/li>\n<li><a href=\"#immune-disorder\" id=\"toc-immune-disorder\">Immune Disorder<\/a><\/li>\n<li><a href=\"#oxidative-stress\" id=\"toc-oxidative-stress\">Oxidative Stress<\/a><\/li>\n<li><a href=\"#lifestyle-factors\" id=\"toc-lifestyle-factors\">Lifestyle Factors<\/a><\/li>\n<\/ul><\/li>\n<li><a href=\"#specific-nutrient-vitamins\" id=\"toc-specific-nutrient-vitamins\">Specific Nutrient: Vitamins<\/a>\n<ul>\n<li><a href=\"#what-is-it\" id=\"toc-what-is-it\">What is it<\/a><\/li>\n<li><a href=\"#how-it-works\" id=\"toc-how-it-works\">How it Works<\/a><\/li>\n<li><a href=\"#what-the-research-is-telling-us\" id=\"toc-what-the-research-is-telling-us\">What the Research is Telling us<\/a><\/li>\n<li><a href=\"#dosage-recommendation-based-on-research\" id=\"toc-dosage-recommendation-based-on-research\">Dosage Recommendation Based on Research<\/a><\/li>\n<li><a href=\"#food-sources\" id=\"toc-food-sources\">Food Sources<\/a><\/li>\n<li><a href=\"#side-effects\" id=\"toc-side-effects\">Side Effects<\/a><\/li>\n<li><a href=\"#bottom-line\" id=\"toc-bottom-line\">Bottom Line<\/a><\/li>\n<\/ul><\/li>\n<li><a href=\"#specific-nutrient-minerals\" id=\"toc-specific-nutrient-minerals\">Specific Nutrient: Minerals<\/a>\n<ul>\n<li><a href=\"#what-is-it-1\" id=\"toc-what-is-it-1\">What is it<\/a><\/li>\n<li><a href=\"#how-it-works-1\" id=\"toc-how-it-works-1\">How it works<\/a><\/li>\n<li><a href=\"#what-the-research-is-telling-us-1\" id=\"toc-what-the-research-is-telling-us-1\">What the Research is Telling Us<\/a><\/li>\n<li><a href=\"#dosage-recommendation-based-on-research-1\" id=\"toc-dosage-recommendation-based-on-research-1\">Dosage Recommendation Based on Research<\/a><\/li>\n<li><a href=\"#food-sources-1\" id=\"toc-food-sources-1\">Food Sources<\/a><\/li>\n<li><a href=\"#side-effects-1\" id=\"toc-side-effects-1\">Side Effects<\/a><\/li>\n<li><a href=\"#bottom-line-1\" id=\"toc-bottom-line-1\">Bottom Line<\/a><\/li>\n<\/ul><\/li>\n<li><a href=\"#specific-nutrient-omega-3-fatty-acid\" id=\"toc-specific-nutrient-omega-3-fatty-acid\">Specific Nutrient: Omega-3 fatty acid<\/a>\n<ul>\n<li><a href=\"#what-is-it-2\" id=\"toc-what-is-it-2\">What is it<\/a><\/li>\n<li><a href=\"#how-it-works-2\" id=\"toc-how-it-works-2\">How it Works<\/a><\/li>\n<li><a href=\"#what-the-research-is-telling-us-2\" id=\"toc-what-the-research-is-telling-us-2\">What the Research is Telling us<\/a><\/li>\n<li><a href=\"#dosage-recommendation-based-on-research-2\" id=\"toc-dosage-recommendation-based-on-research-2\">Dosage Recommendation Based on Research<\/a><\/li>\n<li><a href=\"#food-sources-2\" id=\"toc-food-sources-2\">Food Sources<\/a><\/li>\n<li><a href=\"#side-effects-2\" id=\"toc-side-effects-2\">Side Effects<\/a><\/li>\n<li><a href=\"#bottom-line-2\" id=\"toc-bottom-line-2\">Bottom Line<\/a><\/li>\n<\/ul><\/li>\n<li><a href=\"#specific-nutrient-antioxidants\" id=\"toc-specific-nutrient-antioxidants\">Specific Nutrient: Antioxidants<\/a>\n<ul>\n<li><a href=\"#what-is-it-3\" id=\"toc-what-is-it-3\">What is it<\/a><\/li>\n<li><a href=\"#how-it-works-3\" id=\"toc-how-it-works-3\">How it Works<\/a><\/li>\n<li><a href=\"#what-the-research-is-telling-us-3\" id=\"toc-what-the-research-is-telling-us-3\">What the Research is Telling us<\/a><\/li>\n<li><a href=\"#dosage-recommendation-based-on-research-3\" id=\"toc-dosage-recommendation-based-on-research-3\">Dosage Recommendation Based on Research<\/a><\/li>\n<li><a href=\"#food-sources-3\" id=\"toc-food-sources-3\">Food Sources<\/a><\/li>\n<li><a href=\"#side-effects-3\" id=\"toc-side-effects-3\">Side Effects<\/a><\/li>\n<li><a href=\"#bottom-line-3\" id=\"toc-bottom-line-3\">Bottom Line<\/a><\/li>\n<\/ul><\/li>\n<li><a href=\"#specific-nutrient-amino-acids\" id=\"toc-specific-nutrient-amino-acids\">Specific Nutrient: Amino acids<\/a>\n<ul>\n<li><a href=\"#what-is-it-4\" id=\"toc-what-is-it-4\">What is it<\/a><\/li>\n<li><a href=\"#how-it-works-4\" id=\"toc-how-it-works-4\">How it Works<\/a><\/li>\n<li><a href=\"#what-the-research-is-telling-us-4\" id=\"toc-what-the-research-is-telling-us-4\">What the Research is Telling us<\/a><\/li>\n<li><a href=\"#dosage-recommendation-based-on-research-4\" id=\"toc-dosage-recommendation-based-on-research-4\">Dosage Recommendation Based on Research<\/a><\/li>\n<li><a href=\"#food-sources-4\" id=\"toc-food-sources-4\">Food Sources<\/a><\/li>\n<li><a href=\"#side-effects-4\" id=\"toc-side-effects-4\">Side Effects<\/a><\/li>\n<li><a href=\"#bottom-line-4\" id=\"toc-bottom-line-4\">Bottom Line<\/a><\/li>\n<\/ul><\/li>\n<li><a href=\"#specific-nutrient-spermidine\" id=\"toc-specific-nutrient-spermidine\">Specific Nutrient: Spermidine<\/a>\n<ul>\n<li><a href=\"#what-is-it-5\" id=\"toc-what-is-it-5\">What is it<\/a><\/li>\n<li><a href=\"#how-it-works-5\" id=\"toc-how-it-works-5\">How it Works<\/a><\/li>\n<li><a href=\"#what-the-research-is-telling-us-5\" id=\"toc-what-the-research-is-telling-us-5\">What the Research is Telling us<\/a><\/li>\n<li><a href=\"#dosage-recommendation-based-on-research-5\" id=\"toc-dosage-recommendation-based-on-research-5\">Dosage Recommendation Based on Research<\/a><\/li>\n<li><a href=\"#food-sources-5\" id=\"toc-food-sources-5\">Food Sources<\/a><\/li>\n<li><a href=\"#side-effects-5\" id=\"toc-side-effects-5\">Side Effects<\/a><\/li>\n<li><a href=\"#bottom-line-5\" id=\"toc-bottom-line-5\">Bottom Line<\/a><\/li>\n<\/ul><\/li>\n<li><a href=\"#specific-nutrient-ashwagandha\" id=\"toc-specific-nutrient-ashwagandha\">Specific Nutrient: Ashwagandha<\/a>\n<ul>\n<li><a href=\"#what-is-it-6\" id=\"toc-what-is-it-6\">What is it<\/a><\/li>\n<li><a href=\"#how-it-works-6\" id=\"toc-how-it-works-6\">How it Works<\/a><\/li>\n<li><a href=\"#what-the-research-is-telling-us-6\" id=\"toc-what-the-research-is-telling-us-6\">What the Research is Telling us<\/a><\/li>\n<li><a href=\"#dosage-recommendation-based-on-research-6\" id=\"toc-dosage-recommendation-based-on-research-6\">Dosage Recommendation Based on Research<\/a><\/li>\n<li><a href=\"#side-effects-6\" id=\"toc-side-effects-6\">Side Effects<\/a><\/li>\n<li><a href=\"#bottom-line-6\" id=\"toc-bottom-line-6\">Bottom Line<\/a><\/li>\n<\/ul><\/li>\n<li><a href=\"#specific-nutrient-maca\" id=\"toc-specific-nutrient-maca\">Specific Nutrient: Maca<\/a>\n<ul>\n<li><a href=\"#what-is-it-7\" id=\"toc-what-is-it-7\">What is it<\/a><\/li>\n<li><a href=\"#how-it-works-7\" id=\"toc-how-it-works-7\">How it Works<\/a><\/li>\n<li><a href=\"#what-the-research-is-telling-us-7\" id=\"toc-what-the-research-is-telling-us-7\">What the Research is Telling us<\/a><\/li>\n<li><a href=\"#dosage-recommendation-based-on-research-7\" id=\"toc-dosage-recommendation-based-on-research-7\">Dosage Recommendation Based on Research<\/a><\/li>\n<li><a href=\"#side-effects-7\" id=\"toc-side-effects-7\">Side Effects<\/a><\/li>\n<li><a href=\"#bottom-line-7\" id=\"toc-bottom-line-7\">Bottom Line<\/a><\/li>\n<\/ul><\/li>\n<li><a href=\"#specific-nutrient-red-ginseng\" id=\"toc-specific-nutrient-red-ginseng\">Specific Nutrient: Red Ginseng<\/a>\n<ul>\n<li><a href=\"#what-is-it-8\" id=\"toc-what-is-it-8\">What is it<\/a><\/li>\n<li><a href=\"#how-it-works-8\" id=\"toc-how-it-works-8\">How it Works<\/a><\/li>\n<li><a href=\"#what-the-research-is-telling-us-8\" id=\"toc-what-the-research-is-telling-us-8\">What the Research is Telling us<\/a><\/li>\n<li><a href=\"#dosage-recommendation-based-on-research-8\" id=\"toc-dosage-recommendation-based-on-research-8\">Dosage Recommendation Based on Research<\/a><\/li>\n<li><a href=\"#side-effects-8\" id=\"toc-side-effects-8\">Side Effects<\/a><\/li>\n<li><a href=\"#bottom-line-8\" id=\"toc-bottom-line-8\">Bottom Line<\/a><\/li>\n<\/ul><\/li>\n<li><a href=\"#specific-nutrient-puncturevine\" id=\"toc-specific-nutrient-puncturevine\">Specific Nutrient: Puncturevine<\/a>\n<ul>\n<li><a href=\"#what-is-it-9\" id=\"toc-what-is-it-9\">What is it<\/a><\/li>\n<li><a href=\"#how-it-works-9\" id=\"toc-how-it-works-9\">How it Works<\/a><\/li>\n<li><a href=\"#what-the-research-is-telling-us-9\" id=\"toc-what-the-research-is-telling-us-9\">What the Research is Telling us<\/a><\/li>\n<li><a href=\"#dosage-recommendation-based-on-research-9\" id=\"toc-dosage-recommendation-based-on-research-9\">Dosage Recommendation Based on Research<\/a><\/li>\n<li><a href=\"#side-effects-9\" id=\"toc-side-effects-9\">Side Effects<\/a><\/li>\n<li><a href=\"#bottom-line-9\" id=\"toc-bottom-line-9\">Bottom Line<\/a><\/li>\n<\/ul><\/li>\n<li><a href=\"#multi-nutrients\" id=\"toc-multi-nutrients\">Multi-Nutrients<\/a><\/li>\n<li><a href=\"#who-are-the-experts\" id=\"toc-who-are-the-experts\">Who are the Experts<\/a><\/li>\n<li><a href=\"#positions-and-views-of-worldwide-governmental-medical-and-health-organizations\" id=\"toc-positions-and-views-of-worldwide-governmental-medical-and-health-organizations\">Positions and Views of Worldwide Governmental Medical and Health Organizations<\/a><\/li>\n<li><a href=\"#nonprofits-and-private-organizations\" id=\"toc-nonprofits-and-private-organizations\">Nonprofits and Private Organizations<\/a><\/li>\n<li><a href=\"#social-media-contributors\" id=\"toc-social-media-contributors\">Social Media Contributors<\/a><\/li>\n<li><a href=\"#bibliography\" id=\"toc-bibliography\">Bibliography<\/a><\/li>\n<\/ul>\n<\/nav>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"introduction\">Introduction<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Male infertility is a disease, syndrome, or condition of the male reproductive system that causes failure to achieve a pregnancy. The World Health Organization (WHO) defines male infertility as\u00a0\u201cthe inability of a man to impregnate a fertile woman after at least one year of frequent, unprotected sexual intercourse.\u201d It is estimated that 20-30% of infertility cases are solely due to male factors, and men contribute to 50% of infertility cases overall. The percentage of infertile men globally ranges from 2.5% to\u00a012%. Around 30 million men worldwide are infertile, with the highest rates in Africa and Central\/Eastern Europe, that can account for up to 70% of infertility\u00a0cases. In North America, male infertility rates are estimated at 4-6%, in Australia at 9%, and in Central and Eastern Europe at\u00a08-12%.<a href=\"#fn1\" class=\"footnote-ref\" id=\"fnref1\" role=\"doc-noteref\"><sup>1<\/sup><\/a> In the U.S., 11.4% of men aged 15-49 and 12.8% of men aged 25-49 reported some form of infertility between\u00a02015 to 2019.<a href=\"#fn2\" class=\"footnote-ref\" id=\"fnref2\" role=\"doc-noteref\"><sup>2<\/sup><\/a> A person with infertility is prone to emotional stress, depression, isolation, anxiety, and low self-regard because of the high social value of having a child.<a href=\"#fn3\" class=\"footnote-ref\" id=\"fnref3\" role=\"doc-noteref\"><sup>3<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Male infertility has many causes, including lifestyle factors. Lifestyle factors that can contribute to male infertility include smoking, excessive alcohol consumption, obesity, poor diet, and excessive exercise.<a href=\"#fn4\" class=\"footnote-ref\" id=\"fnref4\" role=\"doc-noteref\"><sup>4<\/sup><\/a> Diet is an essential factor that can positively or negatively impact male fertility.\u00a0A healthy diet can improve semen quality and conception rates. Dietary nutrients have a great effect on male fertility. Scientific studies have indicated that specific nutrients like vitamins, minerals, essential fats, and antioxidants may protect or improve male fertility.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This literature review comprehensively examines the interactions between diet and male fertility. An in-depth exploration of factors affecting male fertility, including lifestyle factors and unhealthy food habits, has been discussed. Considering the evidence supporting the positive effects of dietary nutrients and natural herbs on male fertility, their benefits, drawbacks, or concerns have also been discussed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The discussion begins with an in-depth analysis of the various factors contributing to male infertility, including lifestyle, environmental, and physiological influences. This is followed by a detailed exploration of dietary nutrients and herbs, focusing on their mechanisms of action and the scientific evidence supporting their effectiveness in improving male fertility. Specific topics include dosage recommendations, natural food sources rich in these nutrients, potential side effects, interactions with common medications, and essential safety precautions to ensure proper use. Conclusively, the positions and views of worldwide governmental medical and health organizations, leading experts, and social platforms addressing the issue of male infertility have been discussed.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"significance-of-the-topic\">Significance of the Topic<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Male infertility is increasingly recognized as a significant global health concern. Around 30 million men worldwide are infertile. Male infertility affects a substantial portion of the population, with causes ranging from genetic factors to lifestyle choices and medical\u00a0conditions. Addressing male infertility is significant due to its prevalence and the impact it has on couples trying to conceive. Men often experience emotional distress related to infertility. Men diagnosed with male infertility often experience significant psychological distress, including symptoms of depression, anxiety, and reduced self-esteem.\u00a0The emotional impact is exacerbated by societal norms that stigmatize male infertility, viewing it as a failure of masculinity and an isolating\u00a0experience.<a href=\"#fn5\" class=\"footnote-ref\" id=\"fnref5\" role=\"doc-noteref\"><sup>5<\/sup><\/a> Diet plays a significant role in male infertility. Dietary modifications and the inclusion of specific nutrients and antioxidants can significantly improve health.<a href=\"#fn6\" class=\"footnote-ref\" id=\"fnref6\" role=\"doc-noteref\"><sup>6<\/sup><\/a> Food provides the raw materials required for the body\u2019s metabolic processes, including the production of sperm, maintaining hormone balance, and reproductive health. The present review summarizes the evidence on the relationships between specific dietary components and fertility in men.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"potential-cause-of-male-infertility\">Potential Cause of Male Infertility<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Male infertility is a\u00a0complex condition that involves several factors or causes. However, up to 50% of male infertility cases are classified as unexplained or idiopathic, meaning that the cause is unknown. In the\u00a0remaining 50% of\u00a0cases, various non-adjustable factors (age and genetics) and adjustable factors such as environmental and lifestyle contribute to male infertility. Here are the potential causes of male infertility:<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"hormonal-imbalance\">Hormonal Imbalance<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A healthy reproductive system requires a balanced hormone level. The pituitary gland regulates the production of hormones like testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen, and prolactin. Testosterone, FSH, and LH are primary hormones and regulators of the male reproductive system.<a href=\"#fn7\" class=\"footnote-ref\" id=\"fnref7\" role=\"doc-noteref\"><sup>7<\/sup><\/a> The physiological functions and normal reference range of reproductive hormones in adult men have been provided in Table 1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Table 1 The physiological functions and normal reference range of reproductive hormones in adult men<\/strong><\/em><\/p>\n\n\n\n<div class=\"pcrstb-wrap\"><table style=\"width:100%;\">\n<colgroup>\n<col style=\"width: 20%\" \/>\n<col style=\"width: 57%\" \/>\n<col style=\"width: 21%\" \/>\n<\/colgroup>\n<thead>\n<tr class=\"header\">\n<th><strong>Hormone<\/strong><\/th>\n<th><strong>Function<\/strong><\/th>\n<th><strong>Normal range<\/strong><\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Testosterone<\/th>\n<th>It is the main sex hormone produced\u00a0by the interstitial cells of the testes (Leydig cells). It is required for the development and maturation of sperm cells within the testes, which leads to sperm production.<\/th>\n<th>300-1000 nanograms (ng)\/dL<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>Follicle-stimulating hormone (FSH)<\/th>\n<th>It induces testicular growth and signals the testes to produce sperm through spermatogenesis<\/th>\n<th>1.0-7.6 milli-international unit (mIU)\/ml<\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Luteinizing Hormone (LH)<\/th>\n<th>It stimulates testosterone production\u00a0from the Leydig cells.<\/th>\n<th>1.28-7.8 International unit (IU)\/L<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>Estrogen<\/th>\n<th>It modulates libido, erectile function, and spermatogenesis<\/th>\n<th>10-50 picograms (pg)\/ml<\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Prolactin<\/th>\n<th>It enhances the receptors for LH in the testes.<\/th>\n<th>less than 25 nanograms (ng)\/ml<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<\/tbody>\n<\/table><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Pituitary gland dysfunction causes hormonal imbalance, leading to male infertility. A hormone imbalance occurs when the hormone level rises above or drops below normal levels in the bloodstream. Testosterone levels above or below the normal range can negatively impact male fertility. Abnormally high or low testosterone can suppress sperm production and quality.<a href=\"#fn8\" class=\"footnote-ref\" id=\"fnref8\" role=\"doc-noteref\"><sup>8<\/sup><\/a> Insufficient or overproduction of FSH and LH by the\u00a0pituitary gland causes testicular dysfunction and lowers testosterone levels and sperm production.<a href=\"#fn9\" class=\"footnote-ref\" id=\"fnref9\" role=\"doc-noteref\"><sup>9<\/sup><\/a> Elevated levels of prolactin (15 micrograms (\u03bcg)\/L or more) can inhibit the release of FSH and LH from the pituitary gland\u00a0and hinder sperm production.<a href=\"#fn10\" class=\"footnote-ref\" id=\"fnref10\" role=\"doc-noteref\"><sup>10<\/sup><\/a> The most common causes of\u00a0pituitary gland dysfunction are benign pituitary tumors, poor blood circulation, inflammation, infection, autoimmune disorders, and surgery.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sperm-quality-issue\">Sperm Quality Issue<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">WHO-established normal reference values for human semen quality have been provided in Table 2.<a href=\"#fn11\" class=\"footnote-ref\" id=\"fnref11\" role=\"doc-noteref\"><sup>11<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Table 2 WHO-established normal reference values for human semen quality<\/strong><\/em><\/p>\n\n\n\n<div class=\"pcrstb-wrap\"><table>\n<colgroup>\n<col style=\"width: 23%\" \/>\n<col style=\"width: 53%\" \/>\n<col style=\"width: 23%\" \/>\n<\/colgroup>\n<thead>\n<tr class=\"header\">\n<th><strong>Parameter<\/strong><\/th>\n<th><strong>Description<\/strong><a href=\"#fn12\" class=\"footnote-ref\" id=\"fnref12\" role=\"doc-noteref\"><sup>12<\/sup><\/a><\/th>\n<th><strong>Normal Range<\/strong><\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>pH of semen<\/th>\n<th>The level of acidity or alkalinity of semen<\/th>\n<th>7.2-7.8<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>Semen volume<\/th>\n<th>The amount of semen produced during ejaculation.<\/th>\n<th>Not less than 1.5 ml<\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Sperm count<\/th>\n<th>The number of sperm cells in the given semen sample.<\/th>\n<th>Not less than 39 million<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>Sperm concentration<\/th>\n<th>The number of sperm cells per unit volume (milliliter) of semen.<\/th>\n<th>Not less than 15 million\/ml<\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Sperm vitality<\/th>\n<th>The number of live sperm cells in the semen.<\/th>\n<th>Not less than 58%<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>Sperm motility<\/th>\n<th>The ability of sperm to swim efficiently in a forward direction through the female partner&#8217;s reproductive system to fertilize an egg.<\/th>\n<th>At least 40%<\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Progressive sperm motility<\/th>\n<th>The percentage of sperm that are moving in a straight line or large circles.<\/th>\n<th>At least 32%<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>Total motility<\/th>\n<th>The percentage of sperm that are moving in any direction.<\/th>\n<th>Not less than 40%<\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Normal morphology<\/th>\n<th>The morphology of a sperm includes the shape and size of a sperm&#8217;s head, midpiece, or tail. Normal sperm has an oval head and one long tail.<\/th>\n<th>Not less than 4% of morphologically normal sperm<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>Abnormal morphology<\/th>\n<th>It refers to the irregular or unusual shape of sperm like a large or double or irregularly shaped sperm head; a crooked or double tail; and a short or missing midpiece.<a href=\"#fn13\" class=\"footnote-ref\" id=\"fnref13\" role=\"doc-noteref\"><sup>13<\/sup><\/a><\/th>\n<th>Less than 4% of sperm with normal morphology<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<\/tbody>\n<\/table><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Poor sperm health could be due to abnormally developed testicles, oxidative stress (an imbalance between free radicals and antioxidants), heat exposure (sauna baths and electromagnetic radiation through cell phones and laptops), inflammation of testicles, lifestyle factors, or surgery in or around the testicles<a href=\"#fn14\" class=\"footnote-ref\" id=\"fnref14\" role=\"doc-noteref\"><sup>14<\/sup><\/a> Different types of sperm disorders or abnormalities have been listed in Table 3.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Table 3 Sperm Disorder Description<\/strong><\/em><\/p>\n\n\n\n<div class=\"pcrstb-wrap\"><table>\n<colgroup>\n<col style=\"width: 36%\" \/>\n<col style=\"width: 63%\" \/>\n<\/colgroup>\n<thead>\n<tr class=\"header\">\n<th><strong>Sperm Disorder<\/strong><\/th>\n<th><strong>Description<\/strong><\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Oligozoospermia<\/th>\n<th>A condition in which the men have a low sperm count, usually less than 15 million sperm per milliliter of semen.<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>Azoospermia<\/th>\n<th>A\u00a0medical condition where a man&#8217;s semen contains no sperm\/absent sperm.<\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Asthenozoospermia<\/th>\n<th>A condition characterized by reduced\/poor sperm motility that is, less than 40%.<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>Teratozoospermia<\/th>\n<th>A condition where a significant percentage of sperm cells have abnormal shapes or structures. A lower percentage of normal-shaped sperm cells (typically less than 4%).<\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Asthenoteratospermia<\/th>\n<th>A condition that affects sperm motility and shape. It is a combination of asthenozoospermia and teratozoospermia.<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>Oligoasthenozoospermia<\/th>\n<th>A condition with both oligozoospermia and asthenozoospermia.<\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Oligoasthenoteratozoospermia (OAT)<\/th>\n<th>A condition having a combination of all three oligozoospermia, asthenozoospermia, and teratozoospermia.<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>Ejaculatory duct obstruction.<\/th>\n<th>It refers to a blockage (obstruction) of the ejaculatory duct (sperm duct) that impedes the passage of sperm.<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<\/tbody>\n<\/table><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"immune-disorder\">Immune Disorder<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Infections or inflammation in the prostate, physical trauma to the testicles, surgery in the scrotal region, and autoimmune diseases like lupus, rheumatoid arthritis, or Type I diabetes can generate immune responses that harm sperm through antisperm antibodies (ASA). ASA can hinder spermatogenesis, affecting semen parameters like motility and causing sperm agglutination. Sperm agglutination happens when ASA binds to the sperm\u2019s surface, forming a clump or cluster of sperm cells and hence preventing sperm cells from swimming freely and reaching an egg for fertilization. In the case of ASA, immunosuppressive therapy, artificial insemination, or in vitro fertilization are helpful.<a href=\"#fn15\" class=\"footnote-ref\" id=\"fnref15\" role=\"doc-noteref\"><sup>15<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"oxidative-stress\">Oxidative Stress<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Oxidative stress happens when harmful reactive oxygen species (ROS), also known as free radicals, build up to levels that the body\u2019s natural antioxidant defenses cannot effectively manage. The increased level of ROS can result from environmental factors such as high temperature, electromagnetic waves, air pollution, insecticides, alcohol consumption, sedentary lifestyle, excessive physical exercise, obesity, and poor nutrition. The plasma membrane of sperm consists of high levels of polyunsaturated fatty acids (PUFAs), providing membrane flexibility. PUFAs are prone to oxidation by ROS. ROS negatively affects the\u00a0functional and structural integrity of membrane cells,\u00a0decreases sperm motility, and eventually leads to infertility. ROS also causes sperm DNA damage. Sperm DNA damage may result from diabetes-induced oxidative stress and lipid peroxidation, resulting in poor implantation, embryonic development, and low natality.<a href=\"#fn16\" class=\"footnote-ref\" id=\"fnref16\" role=\"doc-noteref\"><sup>16<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"lifestyle-factors\">Lifestyle Factors<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The lifestyle issues that impact male fertility involve alcohol, unhealthy food habits, stress, obesity, and smoking.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Smoking: Research has correlated smoking to diminished semen parameters such as sperm count, motility, and abnormal morphology. Smoking accelerates sperm DNA fragmentation and oxidative stress. The toxins in cigarette smoke, such as nicotine, cadmium, carbon monoxide, cancer-causing metals, and ROS, impair spermatogenesis and negatively affect the overall quality of sperm. Smoking also causes a hormonal imbalance leading to lower testosterone levels and higher estrogen levels, both of which are detrimental to fertility.<a href=\"#fn17\" class=\"footnote-ref\" id=\"fnref17\" role=\"doc-noteref\"><sup>17<\/sup><\/a> In a study, sperm samples of 63 fertile heavy smokers (20 cigarettes\/day) exhibited a significant decrease in standard semen parameters in comparison to non-smokers.<a href=\"#fn18\" class=\"footnote-ref\" id=\"fnref18\" role=\"doc-noteref\"><sup>18<\/sup><\/a> Smoking cessation can reverse the effects. In a case study, three months of\u00a0smoking cessation showed a significant improvement in sperm quality\u00a0due to reduced oxidative stress markers, allowing for better sperm DNA integrity.<a href=\"#fn19\" class=\"footnote-ref\" id=\"fnref19\" role=\"doc-noteref\"><sup>19<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Excessive Alcohol Consumption: Alcohol overconsumption has been found to drastically affect male reproductive organs, hormones, and semen quality. Alcohol exerts influence on the hypothalamic-pituitary axis instigating suppression of gonadotropin production causing testicular dysfunction, hindered spermatogenesis, increase in oxidative stress and inflammation, decline in testosterone levels, and imbalance between free testosterone and free estrogen.<a href=\"#fn20\" class=\"footnote-ref\" id=\"fnref20\" role=\"doc-noteref\"><sup>20<\/sup><\/a> According to a study, moderate alcohol consumption (40 grams or less daily) displayed no adverse effects on sperm parameters. In contrast, alcohol overindulgence (80-160 grams daily) may hamper male fertility.<a href=\"#fn21\" class=\"footnote-ref\" id=\"fnref21\" role=\"doc-noteref\"><sup>21<\/sup><\/a> Prolonged heavy drinking also contributes to oxidative stress, leading to sperm DNA damage and\u00a0increasing the risk of infertility and stillbirth. A study of 66 men who were given ~180 ml alcohol (40-60% alcohol content) per day for 5 days\/week for 1 year showed significant decrement in semen volume, sperm count, motility, and number of morphologically normal sperm as compared to control. A hormonal imbalance was also observed with significantly higher FSH, LH, and estrogen levels and significantly lower testosterone and prolactin levels.<a href=\"#fn22\" class=\"footnote-ref\" id=\"fnref22\" role=\"doc-noteref\"><sup>22<\/sup><\/a> In a similar study, chronic alcohol consumption was found to give rise to intestinal dysbiosis that causes testicular inflammation and diminished sperm quality.<a href=\"#fn23\" class=\"footnote-ref\" id=\"fnref23\" role=\"doc-noteref\"><sup>23<\/sup><\/a> Moreover, a study of 1221 men revealed that even moderate alcohol consumption (5 units per week) also had a bad effect on standard semen quality.<a href=\"#fn24\" class=\"footnote-ref\" id=\"fnref24\" role=\"doc-noteref\"><sup>24<\/sup><\/a> Fortunately, studies have shown that abstinence from alcohol for several months can restore normal hormone levels and improve sperm quality, typically within three to six months demonstrating that the detrimental effects of alcohol on male fertility can often be reversed through lifestyle changes.<sup>19<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Obesity: Obesity resulting from an unhealthy lifestyle is associated with male infertility as it hinders sperm quality and reproductive hormones. Obesity leads to increased levels of oxidative stress and inflammation, which harm spermatogenesis, causing low sperm count, motility, and abnormal morphology. In obese individuals, disorders on the hypothalamic-pituitary-gonadal axis are observed. The hormonal imbalances due to obesity induce elevated estrogen levels and reduced testosterone production.<a href=\"#fn25\" class=\"footnote-ref\" id=\"fnref25\" role=\"doc-noteref\"><sup>25<\/sup><\/a> Several studies have indicated that weight loss through dietary changes and increased physical activity can significantly improve sperm parameters. Weight loss helps to lower systemic inflammation, reduce oxidative stress, and restore reproductive hormone balance. Specifically, weight loss can raise testosterone levels while decreasing estrogen levels, benefiting spermatogenesis. Additionally, weight loss reduces insulin resistance, which has also been associated with impaired fertility.<a href=\"#fn26\" class=\"footnote-ref\" id=\"fnref26\" role=\"doc-noteref\"><sup>26<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Exercise has a well-documented positive effect on infertility. Regular physical activity promotes hormonal balance, leading to increased testosterone levels and improved spermatogenesis. However, the intensity and type of physical exercise play a crucial role in determining its effect on male reproductive health. A study revealed that moderate-intensity workouts had a\u00a0positive impact on sperm concentration and motility. However, very high-level physical activity might potentially have the\u00a0opposite effect. Moreover, some types of exercise, such as weightlifting (more than 2 hours\/week) and cycling (more than 5 hours\/week), were found to hamper sperm count by causing physical exertion and elevated temperatures in the pelvic area. It concludes that a balanced outlook on exercise and not overexertion helps optimize fertility.<a href=\"#fn27\" class=\"footnote-ref\" id=\"fnref27\" role=\"doc-noteref\"><sup>27<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><span id=\"_heading=h.l07qml6ic2au\" class=\"anchor\"><\/span>Unhealthy Food Habits<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For optimal health and fertility in men, some foods should be avoided, including:\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Highly Processed Food: Food processing is transforming raw agricultural products into food or converting one form of food into another.\u00a0A food classification system called NOVA (not an acronym) categorizes all foods according to the nature, extent, and purposes of the industrial processes they undergo. It divides foods into four groups: unprocessed or minimally processed foods, processed culinary ingredients, processed foods, and ultra-processed foods.<a href=\"#fn28\" class=\"footnote-ref\" id=\"fnref28\" role=\"doc-noteref\"><sup>28<\/sup><\/a> \u00a0NOVA food classification has been discussed in detail in Table 4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Table 4 NOVA food classification system<\/strong><\/em><\/p>\n\n\n\n<div class=\"pcrstb-wrap\"><table>\n<colgroup>\n<col style=\"width: 12%\" \/>\n<col style=\"width: 17%\" \/>\n<col style=\"width: 37%\" \/>\n<col style=\"width: 31%\" \/>\n<\/colgroup>\n<thead>\n<tr class=\"header\">\n<th><strong>Groups<\/strong><\/th>\n<th><strong>Name<\/strong><\/th>\n<th><strong>Description<\/strong><\/th>\n<th><strong>Examples<\/strong><\/th>\n<\/tr>\n<tr class=\"odd\">\n<th rowspan=\"2\">NOVA1<\/th>\n<th>Unprocessed<\/th>\n<th>Unprocessed or natural foods are obtained directly from plants or animals and do not undergo any alteration following their removal from nature.<\/th>\n<th>Fresh fruits and, vegetables, whole grains, eggs, fish, nuts, milk, fresh herbs, plain yogurt, or meat<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>Minimally processed food<\/th>\n<th>A minimally processed food is\u00a0a food (the edible parts of plants or animals that have been taken straight from nature) that has undergone only slight processing like washing, cutting, freezing, canning, or packaging, but with minimal added ingredients to make it easier to store or prepare, but without significantly changing its nutritional value.<\/th>\n<th>Packaged, frozen, or chilled, or pre-cut fruits and vegetables; packaged whole or polished grains; ground chicken; washed-bagged spinach; pasteurized milk, pasteurized vegetable or fruit juices, tea, coffee, or dried fruits<\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>NOVA2<\/th>\n<th>Culinary ingredients<\/th>\n<th>This group includes culinary ingredients such as salt, oil, sugar, or starch, which are produced from NOVA1 foods. They are used in homes and restaurants to season and cook food.<\/th>\n<th>Salt, sugar, honey, butter, vegetable oil, lard, maple syrup, vinegar or starches<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>NOVA3<\/th>\n<th>Processed foods<\/th>\n<th>Processed foods are products manufactured by industry with the use of salt, sugar, oil, or other substances (NOVA2) added to natural or minimally processed foods (NOVA1). Most processed foods have two or three ingredients.<\/th>\n<th>Freshly baked (unpackaged) bread, canned vegetables, cured or smoked meat, bacon, beef jerky, canned fish, fermented alcoholic beverages, salted or sugared nuts and seeds<\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>NOVA 4<\/th>\n<th>Highly processed food or junk food or ultra-processed food or ready-to-eat food<\/th>\n<th>These are industrially formulated products that are \u201cmade mostly or entirely from substances derived from foods and additives, with little if any intact NOVA1 food.<\/th>\n<th>Pre-prepared meat (ham, sausage, hot dogs, deli meats), breakfast cereal, packaged bread, baked goods and soups, frozen meals, instant food, chips, premix, microwave meals, ice cream, sugar-sweetened beverages and yogurt, margarine, infant formula, prepared pizza, pasta dishes, or canned soup<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<\/tbody>\n<\/table><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Highly processed food or drinks are stripped of nutrients and fiber and are high in salt, sugar, bad fat (saturated fat, cholesterol, and trans-fat), harmful preservatives, and additives (artificial color and flavor) that have no nutritional value and can negatively impact sexual health. These foods increase oxidative stress and inflammation in the body, resulting in metabolic disorders that damage reproductive and immune systems, lower sperm quality, and cause an imbalance in hormones.<a href=\"#fn29\" class=\"footnote-ref\" id=\"fnref29\" role=\"doc-noteref\"><sup>29<\/sup><\/a> Studies have shown a link between dietary intake of highly processed meat and low sperm count, concentration, and morphology.<a href=\"#fn30\" class=\"footnote-ref\" id=\"fnref30\" role=\"doc-noteref\"><sup>30<\/sup><\/a> Highly-processed meat may also contain high concentrations of xenoestrogens and, in some cases, steroids that influence semen quality and reproductive hormone levels. Xenoestrogens are synthetic chemicals that disrupt hormone balances in the body by mimicking natural estrogen hormones and hindering estrogen binding to its receptors. Examples include pesticides, petrochemicals, herbicides, chlorinated pollutants, and bisphenol A.<a href=\"#fn31\" class=\"footnote-ref\" id=\"fnref31\" role=\"doc-noteref\"><sup>31<\/sup><\/a> However, it should be mentioned that not every type of processed food is necessarily bad for our health. For example, minimally processed food should be preferred over processed food.<a href=\"#fn32\" class=\"footnote-ref\" id=\"fnref32\" role=\"doc-noteref\"><sup>32<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Seafood High in Mercury: Eating fish is good, but fish contaminated with mercury are bad for the reproductive system.<a href=\"#fn33\" class=\"footnote-ref\" id=\"fnref33\" role=\"doc-noteref\"><sup>33<\/sup><\/a> Mercury is a heavy metal and may act as a spermatotoxicant affecting spermatogenesis, sperm motility, and morphology.<a href=\"#fn34\" class=\"footnote-ref\" id=\"fnref34\" role=\"doc-noteref\"><sup>34<\/sup><\/a> Due to bioaccumulation, large fish with long lifespans contain more mercury like swordfish, marlin, mollusks, mackerel, tuna, and tilefish.\u00a0Hence, go for lower-mercury seafood such as salmon, anchovy cod, scallops, oysters, squid, sardines, and shrimp.<a href=\"#fn35\" class=\"footnote-ref\" id=\"fnref35\" role=\"doc-noteref\"><sup>35<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Caffeine: Caffeine is a naturally occurring psychoactive chemical that has a central nervous system-stimulating effect. Frequent or excessive intake of caffeine (more than 800 mg\/day) has been associated with reduced sperm count and concentration, altered spermatogenesis, and testicular function.<a href=\"#fn36\" class=\"footnote-ref\" id=\"fnref36\" role=\"doc-noteref\"><sup>36<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Refined Sugar: Excessive intake of glucose or refined sugars, in the form of cakes, fries, chocolate, confectionery, syrups, table sugar, white bread, soft drinks, sweets, processed and packaged bars and snacks, ice cream, ketchup, and sauces, harms semen quality. Regular and excessive consumption of sugar is associated with an increased risk of developing prediabetes and greater insulin resistance.<a href=\"#fn37\" class=\"footnote-ref\" id=\"fnref37\" role=\"doc-noteref\"><sup>37<\/sup><\/a> With higher insulin resistance, more oxidative stress can negatively influence testosterone levels, sperm production, and motility by disrupting the hypothalamic\u2013pituitary\u2013testicular axis.<a href=\"#fn38\" class=\"footnote-ref\" id=\"fnref38\" role=\"doc-noteref\"><sup>38<\/sup><\/a> Many animal-based studies revealed that a high-sugar diet may damage sperm quality permanently, with an increase in testicular weight and abnormal testosterone levels.<a href=\"#fn39\" class=\"footnote-ref\" id=\"fnref39\" role=\"doc-noteref\"><sup>39<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In a study on 2935 young men, men consuming sugar-sweetened beverages (~200 ml serving\/day) showed comparatively low sperm count, concentration, and motility compared to the non-consumers who opted for water.<a href=\"#fn40\" class=\"footnote-ref\" id=\"fnref40\" role=\"doc-noteref\"><sup>40<\/sup><\/a> In a cross-sectional study, it was found that even a moderate intake of artificially sweetened beverages (\u2265 3 days per week) could lower the number of morphologically normal sperm.<a href=\"#fn41\" class=\"footnote-ref\" id=\"fnref41\" role=\"doc-noteref\"><sup>41<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Soy:\u00a0The relationship between soy food consumption and male infertility has been a topic of interest due to the presence of phytoestrogens, such as isoflavones, in soy products.\u00a0Phytoestrogens are plant-based compounds that resemble estrogen structures and have an anti-estrogenic effect. Phytoestrogens can alter the expression of estrogen and testosterone receptors, which may disrupt the hormonal regulation of the reproductive system.\u00a0Some studies found a deleterious impact of high soy-based food consumption on sperm concentration in men.<a href=\"#fn42\" class=\"footnote-ref\" id=\"fnref42\" role=\"doc-noteref\"><sup>42<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Packaged food:\u00a0Food packed in plastic food containers or metal cans can negatively impact male fertility due to the presence of bisphenol A (BPA).\u00a0BPA is an industrial chemical that is used to make polycarbonate plastic and epoxy resins. Metal cans are mostly coated with epoxy resin to avoid corrosion and to combat the sterilization process. BPA can leach from the plastic container or cans into the food or drinks. In the body, BPA acts as an endocrine-disrupting chemical or xenoestrogen that mimics estrogen. BPA can negatively interfere with sperm motility and disturb hormone balance and mitochondrial function in the testes.<a href=\"#fn43\" class=\"footnote-ref\" id=\"fnref43\" role=\"doc-noteref\"><sup>43<\/sup><\/a> It also alters fertility-related protein levels in spermatozoa.<a href=\"#fn44\" class=\"footnote-ref\" id=\"fnref44\" role=\"doc-noteref\"><sup>44<\/sup><\/a> Glass jars and BPA-free cans are good alternatives.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"specific-nutrient-vitamins\">Specific Nutrient: Vitamins<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-it\">What is it<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Vitamins are micronutrients required in small quantities for good health. This is due to the antioxidant capacity of vitamins and some vitamins&#8217; role in many biological or metabolic processes as a cofactor.\u00a0Specifically, some vitamins like vitamin D, vitamin E, vitamin B9 (folic acid), and vitamin C may help in improving male fertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"how-it-works\">How it Works<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Vitamin D is a vitamin that helps the body absorb calcium. It regulates calcium homeostasis or calcium influx in the testes and spermatozoa, which is an essential process required for sperm motility.<a href=\"#fn45\" class=\"footnote-ref\" id=\"fnref45\" role=\"doc-noteref\"><sup>45<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vitamin E acts as an antioxidant that protects sperm by neutralizing free radicals in the testes, protecting sperm cell membranes from oxidative damage and reducing DNA damage.<a href=\"#fn46\" class=\"footnote-ref\" id=\"fnref46\" role=\"doc-noteref\"><sup>46<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vitamin C has antioxidant capacity, and it can be found in high concentrations in seminal plasma and prohibits sperm DNA damage through ROS.<a href=\"#fn47\" class=\"footnote-ref\" id=\"fnref47\" role=\"doc-noteref\"><sup>47<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Folic acids, also known as vitamin B9 or folates, are vitamins that act as an essential cofactor required by enzymes involved in protein synthesis, cell division, and methylation of DNA. They play a central role in spermatogenesis, stabilizing sperm count, and maintaining healthy hormone levels. Folate prevents hyperhomocysteinemia, a condition associated with low semen parameters.<a href=\"#fn48\" class=\"footnote-ref\" id=\"fnref48\" role=\"doc-noteref\"><sup>48<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-the-research-is-telling-us\">What the Research is Telling us<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Recent studies have found a positive correlation between vitamin D levels and sperm motility. The normal range of vitamin D levels in the blood for adult men is 30 nanogram\/ml or more. A deficiency in vitamin D is associated with lower semen parameters like motility.\u00a0A significant improvement in sperm motility was observed in 3 months of daily vitamin D supplementation (4000 IU\/day) in 86 asthenozoospermia (low sperm motility) infertile men with vitamin D deficiency (serum level of vitamin D less than 30 nanogram\/ml). However, no significant effect of vitamin D supplementation was observed on semen volume, sperm count, or sperm morphology.<a href=\"#fn49\" class=\"footnote-ref\" id=\"fnref49\" role=\"doc-noteref\"><sup>49<\/sup><\/a> More dedicated clinical studies are needed to clarify the exact role of vitamin D in male fertility, particularly regarding its effects on hormonal and seminal parameters.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vitamin E, mostly in combination with other nutrients, showed efficiency in treating male infertility. Vitamin E supplement (100 mg) in combination with coenzyme Q (10 mg) three times daily for 3 months was observed to be effective in enhancing sperm motility, morphology, and testosterone levels in 73 infertile men with idiopathic infertility.<a href=\"#fn50\" class=\"footnote-ref\" id=\"fnref50\" role=\"doc-noteref\"><sup>50<\/sup><\/a> Antioxidant supplement treatment (1 gram of vitamin C and 1 gram of vitamin E) for 2 months given to 64 men with idiopathic infertility reduced the level of DNA damage in spermatozoa.<a href=\"#fn51\" class=\"footnote-ref\" id=\"fnref51\" role=\"doc-noteref\"><sup>51<\/sup><\/a> The efficacy of vitamin E in treating male infertility is controversial, however, with some studies showing no significant improvements in sperm parameters after vitamin E treatment\u00a0alone. For instance, in a study, daily consumption of an oral synthetic vitamin E supplement (400 IU or 180 mg\/day) for 2 months showed no statistically significant change in sperm volume, sperm count, motility, and morphology in 61 men with idiopathic infertility.<a href=\"#fn52\" class=\"footnote-ref\" id=\"fnref52\" role=\"doc-noteref\"><sup>52<\/sup><\/a> The current body of research presents mixed results, and there is a need for more well-defined clinical studies to establish the efficacy of vitamin E in male infertility treatment.\u00a0Long-term studies are required to assess the impact of vitamin E on live birth rates and to determine the most effective combinations of antioxidants for improving male fertility\u00a0outcomes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Varicocele (swollen veins in the scrotum) is one of the most common causes of male infertility. Vitamin C has been shown to improve sperm motility and morphology, particularly in men who have undergone varicocele surgery. In one study, 115 men with infertility receiving vitamin C supplements (250 mg\/day) after varicocelectomy surgery (a surgical procedure to treat varicoceles) exhibited improved sperm motility and morphology, although the supplementation did not significantly affect sperm\u00a0count.<a href=\"#fn53\" class=\"footnote-ref\" id=\"fnref53\" role=\"doc-noteref\"><sup>53<\/sup><\/a> Furthermore, an improved sperm parameter (sperm count, morphology, and motility) was observed in 2 months of twice-daily supplementation of vitamin C (1000 mg\/day) in 13 infertile men.<a href=\"#fn54\" class=\"footnote-ref\" id=\"fnref54\" role=\"doc-noteref\"><sup>54<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In another study, high-dose folic acid supplementation (15 mg\/day; 3 tablets 5 mg each) decreased DNA fragmentation in sperm, a positive indicator for fertility, although it did not significantly change other sperm characteristics such as concentration or\u00a0motility in 162 infertile men.<a href=\"#fn55\" class=\"footnote-ref\" id=\"fnref55\" role=\"doc-noteref\"><sup>55<\/sup><\/a> A study has shown that daily consumption of folic acid (5 mg\/day), in combination with tamoxifen citrate acid (20 mg\/day) for 3 months, increased sperm concentration and motility in 68 infertile men.<a href=\"#fn56\" class=\"footnote-ref\" id=\"fnref56\" role=\"doc-noteref\"><sup>56<\/sup><\/a> However, a study on 2370 men seeking infertility treatment failed to show significant improvement in sperm quality when given zinc supplement (30 mg) in combination with folic acid (5 mg) for 6 months.<a href=\"#fn57\" class=\"footnote-ref\" id=\"fnref57\" role=\"doc-noteref\"><sup>57<\/sup><\/a> Given the mixed results of previous studies, further well-designed clinical trials are necessary to better understand the role of folic acid, both alone and in combination with other supplements in treating male infertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"dosage-recommendation-based-on-research\">Dosage Recommendation Based on Research<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Recommended dietary allowances (RDA) or minimum daily recommended intake of different vitamins for adult men (age more than 14 years) according to National Institutes of Health (NIH) include vitamin D [15 micrograms (\u00b5g)\/day or 600 IU]; vitamin C (75-90 mg\/day); vitamin E (15 mg\/day), and vitamin B9 or folic acid (400 \u00b5g\/day).<a href=\"#fn58\" class=\"footnote-ref\" id=\"fnref58\" role=\"doc-noteref\"><sup>58<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Recommended dosages of different vitamins for specific sperm parameters include vitamin D (4000 IU) for sperm motility; vitamin C (1000 mg\/day) for improving sperm count, motility, and morphology; vitamin E (100 mg\/day) for enhancing sperm motility, morphology, and testosterone levels; and vitamin B9 or folic acid (400 \u00b5g\/day) for increasing sperm concentration and motility and reducing sperm DNA fragmentation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Table 5 Dosage Recommendation of Vitamins for Adult Men (age more than 14 years)<\/strong><\/em><\/p>\n\n\n\n<div class=\"pcrstb-wrap\"><table>\n<colgroup>\n<col style=\"width: 12%\" \/>\n<col style=\"width: 22%\" \/>\n<col style=\"width: 22%\" \/>\n<col style=\"width: 22%\" \/>\n<col style=\"width: 19%\" \/>\n<\/colgroup>\n<thead>\n<tr class=\"header\">\n<th><strong>Nutrient<\/strong><\/th>\n<th><strong>Minimum daily recommended intake for adult men<\/strong><\/th>\n<th><strong>Daily recommended dosage for better semen parameters<\/strong><\/th>\n<th><strong>Don\u2019t take more than<\/strong><\/th>\n<th><strong>When will I see results?<\/strong><\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Vitamin D<\/th>\n<th>15 \u00b5g\/day or 600 IU<\/th>\n<th>100\u00b5g or 4000 IU\/day for sperm motility<\/th>\n<th>100 \u00b5g\/day or 4000 IU\/day<\/th>\n<th>6 to 12 weeks<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>Vitamin C<\/th>\n<th>75-90 milligrams (mg)\/day<\/th>\n<th>1000 mg\/day for sperm count, motility, and morphology<\/th>\n<th>1800-2000 mg\/day<\/th>\n<th>6 to 12 weeks<\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Vitamin E<\/th>\n<th>15 mg\/day<\/th>\n<th>100 mg\/day for sperm motility, morphology, and testosterone levels<\/th>\n<th>800-1000 mg\/day<\/th>\n<th>6 to 12 weeks<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>Vitamin B9 (Folic acid or folate)<\/th>\n<th>400 \u00b5g\/day<\/th>\n<th>400 \u00b5g\/day for improving sperm concentration and motility, and reducing sperm DNA fragmentation<\/th>\n<th>800-1000 \u00b5g\/day<\/th>\n<th>6 to 12 weeks<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<\/tbody>\n<\/table><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"food-sources\">Food Sources<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Plant sources that provide Vitamin D include:<a href=\"#fn59\" class=\"footnote-ref\" id=\"fnref59\" role=\"doc-noteref\"><sup>59<\/sup><\/a><\/p>\n\n\n\n<ul>\n<li><p>Mushroom: 2300 IU\/100 gram, 383% of the Daily Recommended Value (DV)<\/p><\/li>\n<\/ul>\n\n\n\n<ul>\n<li><p>Orange juice: 100 IU per cup, 16% of DV<\/p><\/li>\n<li><p>Soy Milk: 107-117 IU per cup, 19% of DV<\/p><\/li>\n<li><p>Fortified cereal: 85-145 IU per cup, 11-18% of DV<\/p><\/li>\n<li><p>Fortified orange juice: 100 IU per cup, 12% of DV<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Animal sources that provide Vitamin D include:<\/p>\n\n\n\n<ul>\n<li><p>Tofu: 100 IU\/100 gram, 16% of DV<\/p><\/li>\n<li><p>Canned sardines: 193 IU\/100 gram, 32% of DV<\/p><\/li>\n<li><p>Cheese: 24 IU\/100 gram, 4% of DV<\/p><\/li>\n<li><p>Cod liver oil: 450 IU\/teaspoon, 50% of DV<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Plant sources with the highest amount of vitamin C include:<a href=\"#fn60\" class=\"footnote-ref\" id=\"fnref60\" role=\"doc-noteref\"><sup>60<\/sup><\/a><\/p>\n\n\n\n<ul>\n<li><p>Guava: 125 mg per fruit, 138% of DV<\/p><\/li>\n<li><p>Kiwi: 56 mg per fruit, 62% of DV<\/p><\/li>\n<li><p>Orange: 83 mg per fruit, 92% of DV<\/p><\/li>\n<li><p>Raw kale: 93 mg of Vitamin C per 100 g, 103% of DV<\/p><\/li>\n<li><p>Black currants: 102 mg per half cup (56 g), 113% of DV<\/p><\/li>\n<li><p>Yellow Bell pepper(chopped): 342 mg per cup, 342% of DV<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Animal sources with the highest amount of vitamin C are:<\/p>\n\n\n\n<ul>\n<li><p>Raw Chicken liver: 17.9 mg per 100g, 19.8% of DV<\/p><\/li>\n<li><p>Beef Lungs: 32.7 mg per 100 g, 36.3% of DV<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Plant sources providing a good amount of vitamin E include:<a href=\"#fn61\" class=\"footnote-ref\" id=\"fnref61\" role=\"doc-noteref\"><sup>61<\/sup><\/a><\/p>\n\n\n\n<ul>\n<li><p>Wheat germ oil: 150 mg\/100 g, 1000% of DV<\/p><\/li>\n<li><p>Almond:15 mg\/100 g, 100% of DV<\/p><\/li>\n<li><p>Dried apricot: 4 mg\/100 g, 26% of DV<\/p><\/li>\n<li><p>Sunflower seed: 35 mg\/100 g, 233% of DV<\/p><\/li>\n<li><p>Avocado: 3.1 mg per fruit, 20% of DV<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Animal sources providing a good amount of vitamin E include:<\/p>\n\n\n\n<ul>\n<li><p>Goose meat: 1.7 mg\/100 g, 11% of DV<\/p><\/li>\n<li><p>Cod: 0.8 mg\/100 g, 5% of DV<\/p><\/li>\n<li><p>Abalone: 3.4 mg\/100 g, 23% of DV<\/p><\/li>\n<li><p>Goose meat: 2.4 mg\/100 g, 16% of DV<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Plant sources that provide Vitamin B9 or folic acid include:<a href=\"#fn62\" class=\"footnote-ref\" id=\"fnref62\" role=\"doc-noteref\"><sup>62<\/sup><\/a><\/p>\n\n\n\n<ul>\n<li><p>Kidney beans (cooked): 131 \u00b5g per cup, 32% of DV<\/p><\/li>\n<li><p>Asparagus (cooked): 134 \u00b5g per half cup, 33% of DV<\/p><\/li>\n<li><p>Brussel sprouts (cooked): 47 \u00b5g per half cup, 11% of DV<\/p><\/li>\n<li><p>Broccoli (cooked): 84 \u00b5g per half cup, 21% of DV<\/p><\/li>\n<li><p>Raw spinach: 58.2 \u00b5g\/30g, 15% of DV<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Animal sources that provide Vitamin B9 or folic acid include:<\/p>\n\n\n\n<ul>\n<li><p>Beef liver (cooked): 212 \u00b5g per half cup, 53% of DV<\/p><\/li>\n<li><p>Egg: 22 \u00b5g per egg, 6% of DV<\/p><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"side-effects\">Side Effects<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Common side effects: Too much (more than 4000 IU) vitamin D supplementation daily can cause side effects like itchy skin, sore eyes, stomach pain, diarrhea, or vomiting.<a href=\"#fn63\" class=\"footnote-ref\" id=\"fnref63\" role=\"doc-noteref\"><sup>63<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Side effects of high doses of vitamin C (more than 2000 mg\/day) include diarrhea, stomach cramps, and nausea.<a href=\"#fn64\" class=\"footnote-ref\" id=\"fnref64\" role=\"doc-noteref\"><sup>64<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">High doses (1000 mg\/day) of vitamin E may cause side effects like headaches, nausea, fatigue, and bleeding.<a href=\"#fn65\" class=\"footnote-ref\" id=\"fnref65\" role=\"doc-noteref\"><sup>65<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Side effects of folic acid are uncommon but may include allergic reactions like rash, itching, and redness.<a href=\"#fn66\" class=\"footnote-ref\" id=\"fnref66\" role=\"doc-noteref\"><sup>66<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Drug interactions: Vitamin D supplementation may interact with medications like diuretics, antiarrhythmic drugs, blood pressure regulators, laxatives, and corticosteroids.<sup>63<\/sup> Vitamin C supplements might interfere with cancer treatments, such as chemotherapy and radiation therapy.<sup>64<\/sup> Vitamin E may interact with blood thinners (e.g., warfarin, aspirin).<sup>65<\/sup> Folic acid supplements may interact with alcohol and medications such as antibiotics and anticonvulsants.<sup>66<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Safety precautions: Nutrients in the form of dietary supplements should only be taken after consulting a doctor or other healthcare professional for safety. Supplements can interact with other supplements or medications, so a healthcare provider&#8217;s help is required to decide what supplement is right for you. Always remember that supplements cannot replace a well-balanced, healthy diet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"bottom-line\">Bottom Line<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Strength of recommendations: Vitamin D appears to have a positive effect on certain aspects of semen quality, particularly sperm motility, but its overall impact on male fertility and hormonal balance requires further investigation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vitamin E has shown significant improvements in sperm parameters and hormone levels (sperm motility, morphology, and testosterone levels) compared to vitamin E alone, indicating that combination therapies (with other nutrients) might be more\u00a0effective. The current body of this research also presents mixed results, and there is a need for more well-defined clinical studies to establish the efficacy of vitamin E in male infertility treatment. Factors such as dosage and duration of treatment still need to be\u00a0standardized.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vitamin C exhibits high potential in improving certain aspects of sperm quality (sperm count, motility, and morphology). However, its direct impact on fertility outcomes such as pregnancy and live birth rates requires further investigation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Folic acid supplementation shows some promise in improving certain sperm parameters (sperm concentration and motility) and reducing sperm DNA fragmentation. Nonetheless, more research is needed to establish clear guidelines for its use in male infertility treatment.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"specific-nutrient-minerals\">Specific Nutrient: Minerals<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-it-1\">What is it<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Minerals in food are\u00a0inorganic nutrients that are essential, like vitamins. Minerals are required in small quantities for the variety of metabolic processes in the body. The body cannot produce minerals on its own; hence, they must be obtained through food or supplements. Minerals\u00a0like zinc and selenium have a vital role in male infertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"how-it-works-1\">How it works<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Zinc is the second most abundant trace element in the\u00a0human body after iron. Zinc has high antioxidant potential and antibacterial effects. Zinc is an essential mineral that plays a role as a cofactor for enzymes involved in cell division required for sperm formation, hormone balance, and cell motility. Its antioxidant capacity and antibacterial properties help maintain the epithelial integrity of sperm and prevent urinary infection.<a href=\"#fn67\" class=\"footnote-ref\" id=\"fnref67\" role=\"doc-noteref\"><sup>67<\/sup><\/a> Selenium is an essential trace element that acts as a cofactor for antioxidant enzymes that protect sperm from oxidative damage, maintain normal sperm structure integrity, and are involved in the formation of sperm and testosterone production.<a href=\"#fn68\" class=\"footnote-ref\" id=\"fnref68\" role=\"doc-noteref\"><sup>68<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-the-research-is-telling-us-1\">What the Research is Telling Us<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A study involving 45 infertile men with asthenozoospermia (poor sperm motility) demonstrated that zinc supplementation improved sperm parameters by reducing oxidative stress, sperm apoptosis (programmed cell death), and sperm DNA fragmentation.<a href=\"#fn69\" class=\"footnote-ref\" id=\"fnref69\" role=\"doc-noteref\"><sup>69<\/sup><\/a> A daily dietary intake of 11 mg is needed, especially in males, as zinc is not stored in the body. Zinc deficiency (serum zinc level below 70 \u03bcg\/dL) impedes spermatogenesis, resulting in sperm abnormalities and reduced sperm fertilization capacity. Zinc deficiency can arise due to high oxidative stress and smoking.<sup>67<\/sup> Studies have shown that zinc levels in the seminal plasma of infertile males were significantly lower than those of normal males. This suggests a potential link between zinc deficiency and male\u00a0infertility.<a href=\"#fn70\" class=\"footnote-ref\" id=\"fnref70\" role=\"doc-noteref\"><sup>70<\/sup><\/a> However, further studies are needed to better elucidate the correlation between seminal plasma zinc and male infertility.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">On the contrary, in a study on couples seeking infertility treatment, 2370 men did not show significant improvement in sperm quality when given zinc supplements (30 mg) in combination with folic acid (5 mg) for 6 months.<a href=\"#fn71\" class=\"footnote-ref\" id=\"fnref71\" role=\"doc-noteref\"><sup>71<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">While some studies support the beneficial effects of zinc on male fertility, other results are inconsistent, indicating the need for further research to clarify the relationship between zinc levels and\u00a0infertility. Future studies should focus on understanding the optimal dosage and duration of zinc supplementation and its interaction with other micronutrients to maximize its benefits for male\u00a0fertility.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Selenium is an essential trace element that plays a crucial role in reproductive health, particularly in male fertility. A study of 69 patients with low selenium profile showed improvement in sperm motility when given a selenium supplement alone or in combination with vitamins A, C, and E for 3 months.<a href=\"#fn72\" class=\"footnote-ref\" id=\"fnref72\" role=\"doc-noteref\"><sup>72<\/sup><\/a> Another study involving 690 infertile men with idiopathic asthenoteratospermia indicated that daily supplementation of selenium (200 \u03bcg) in combination with vitamin E (400 units) for 100 days enhanced sperm morphology and motility in 352 cases.<a href=\"#fn73\" class=\"footnote-ref\" id=\"fnref73\" role=\"doc-noteref\"><sup>73<\/sup><\/a> A combined effect of selenium (200 \u03bcg) with N-acetylcysteine (a strong antioxidant medicine) (600 mg) daily oral supplement on 468 infertile men with idiopathic oligoasthenoteratospermia was observed for 26 weeks. Resulting in improved semen parameters (concentration, motility, and morphology).<a href=\"#fn74\" class=\"footnote-ref\" id=\"fnref74\" role=\"doc-noteref\"><sup>74<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"dosage-recommendation-based-on-research-1\">Dosage Recommendation Based on Research<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">According to the National Institutes of Health (NIH), the recommended dietary allowances (RDA) or minimum daily recommended intake for adult men (age more than 14 years) for zinc is 11 mg\/day and 55 \u00b5g\/day for selenium.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Recommended dosages of minerals for specific sperm parameters include zinc (11 mg\/day) for preventing DNA fragmentation and apoptosis of sperm cells and selenium (200 \u03bcg\/day) for improving sperm concentration, motility, and morphology.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Table 6 Dosage Recommendation of Certain Minerals for Adult Men (age more than 14 years)<\/strong><\/em><\/p>\n\n\n\n<div class=\"pcrstb-wrap\"><table>\n<colgroup>\n<col style=\"width: 12%\" \/>\n<col style=\"width: 21%\" \/>\n<col style=\"width: 25%\" \/>\n<col style=\"width: 18%\" \/>\n<col style=\"width: 22%\" \/>\n<\/colgroup>\n<thead>\n<tr class=\"header\">\n<th><strong>Nutrient<\/strong><\/th>\n<th><strong>Minimum daily recommended intake for adult men<\/strong><\/th>\n<th><strong>Daily recommended dosage for better semen parameters<\/strong><\/th>\n<th><strong>Don\u2019t take more than<\/strong><\/th>\n<th><strong>When will I see results?<\/strong><\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Zinc<\/th>\n<th>11 mg\/day<\/th>\n<th>11 mg\/day for preventing DNA fragmentation and apoptosis of sperm cells<\/th>\n<th>34-40 mg\/day<\/th>\n<th>6 to 12 weeks<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>Selenium<\/th>\n<th>55 \u00b5g\/day<\/th>\n<th>200 \u03bcg\/day for sperm concentration, motility, and morphology<\/th>\n<th>400 \u00b5g\/day<\/th>\n<th>6 to 12 weeks<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<\/tbody>\n<\/table><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"food-sources-1\">Food Sources<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Plant sources with the most zinc are:<a href=\"#fn75\" class=\"footnote-ref\" id=\"fnref75\" role=\"doc-noteref\"><sup>75<\/sup><\/a><\/p>\n\n\n\n<ul>\n<li><p>Pumpkin seeds: 8.4 mg per half cup, 57% of DV<\/p><\/li>\n<li><p>Cashews: 6 mg\/100 g, 54% of DV<\/p><\/li>\n<li><p>Hemp seeds: 3 mg\/30 g, 27% of DV<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Animal sources with the most zinc are:<\/p>\n\n\n\n<ul>\n<li><p>Lobster: 4 mg\/100 g of meat, 36% of DV<\/p><\/li>\n<li><p>Beef chuck: 8.47 mg\/100 g, 77% of DV<\/p><\/li>\n<li><p>Lamb shank: 8.67 mg\/100 g, 78% of DV<\/p><\/li>\n<li><p>Raw ground beef: 4.79 mg\/100 g, 44% of DV<\/p><\/li>\n<li><p>Alaska king crab: 7.62 mg\/100 g, 69% of DV<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Plant sources high in selenium include:<a href=\"#fn76\" class=\"footnote-ref\" id=\"fnref76\" role=\"doc-noteref\"><sup>76<\/sup><\/a><\/p>\n\n\n\n<ul>\n<li><p>Brazil nut: 68-91 \u03bcg per nut, 165% of DV<\/p><\/li>\n<li><p>Firm tofu: 17.4 \u03bcg\/100 g, 31% of DV<\/p><\/li>\n<li><p>Whole wheat pasta (cooked): 36.3 \u03bcg per cup, 53% of DV<\/p><\/li>\n<li><p>Cottage cheese: 20 \u03bcg per cup, 36% of DV<\/p><\/li>\n<li><p>Cooked brown rice: 19 \u03bcg per cup, 35% of DV<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Animal sources high in selenium include:<\/p>\n\n\n\n<ul>\n<li><p>Lean pork chops: 47.4 \u03bcg\/100 g<\/p><\/li>\n<li><p>Roasted beefsteak: 33 \u03bcg\/85 g, 47% of DV<\/p><\/li>\n<li><p>Roasted turkey: 31 \u03bcg\/85 g, 44% of DV<\/p><\/li>\n<li><p>Beef liver (pan-fried): 28 \u03bcg\/85 g, 40% of DV<\/p><\/li>\n<li><p>Cooked Tuna: 92 \u03bcg\/85 g, 131% of DV<\/p><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"side-effects-1\">Side Effects<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Common side effects: Taking very high doses of zinc (more than 40 mg) may cause side effects like stomach pain, diarrhea, or vomiting.<a href=\"#fn77\" class=\"footnote-ref\" id=\"fnref77\" role=\"doc-noteref\"><sup>77<\/sup><\/a> Common side effects of high doses (more than 400 \u03bcg) of selenium are nausea, bad breath, hair loss, tiredness, and fever.<a href=\"#fn78\" class=\"footnote-ref\" id=\"fnref78\" role=\"doc-noteref\"><sup>78<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Drug interaction: Zinc may interfere with medications such as antibiotics, non-steroidal anti-inflammatory drugs, blood pressure regulators, and immunosuppressants. Selenium may interact with medications like sedatives, immunosuppressants, anticoagulants, or antiplatelet drugs.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Safety Precautions: Check with your healthcare\u00a0provider\u00a0or dietitian\u00a0before taking\u00a0any\u00a0supplements.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"bottom-line-1\">Bottom Line<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Strength of recommendations: While zinc is vital for male reproductive health and can improve certain sperm parameters, its direct impact on fertility outcomes requires further investigation. More comprehensive studies are needed to establish effective supplementation strategies for treating male infertility.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Selenium supplementation shows potential in improving semen quality (sperm concentration, motility, and morphology) and addressing male infertility, particularly when combined with other antioxidants. However, further research is needed to fully understand its effects and establish standardized treatment protocols.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"specific-nutrient-omega-3-fatty-acid\">Specific Nutrient: Omega-3 fatty acid<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-it-2\">What is it<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Omega-3 fatty acids are essential fats or essential fatty acids. These essential fats cannot be produced in the body and have to be acquired from the diet for the\u00a0proper functioning of the body.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"how-it-works-2\">How it Works<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Studies positively correlated a\u00a0diet rich in omega-3 fatty acids with better sperm quality. Omega-3 fatty acids provide structure and integrity to sperm membranes and improve sperm motility and morphology. It combats male infertility due to its anti-inflammatory properties and antioxidant potential. Excessive inflammation activates an enzyme called aromatase that converts testosterone into estrogen, causing low testosterone levels and hormone imbalance. Omega-3 fatty acids counter the effects of that aromatase enzyme. Omega-3 fatty acids protect sperm from oxidative damage. It acts as a vasodilator and widens the blood vessels, leading to increased blood circulation to the sexual organ.<a href=\"#fn79\" class=\"footnote-ref\" id=\"fnref79\" role=\"doc-noteref\"><sup>79<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-the-research-is-telling-us-2\">What the Research is Telling us<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">According to research, omega-3 fatty acids can potentially benefit men experiencing infertility issues by improving semen quality. In an eight-month study of 238 men suffering from oligoasthenoteratospermia, omega-3 fatty acids administration (1.84 g\/day) improved total sperm count and sperm concentration.<a href=\"#fn80\" class=\"footnote-ref\" id=\"fnref80\" role=\"doc-noteref\"><sup>80<\/sup><\/a> In another study of 119 men, an omega-3 fatty acids-rich diet comprising mixed nuts (60 g\/day) for 14 weeks showed a positive effect on total sperm count, morphology, vitality, and motility. Also, sperm DNA fragmentation was significantly reduced in comparison to the control group. The mixed nuts comprised 30 g of walnuts, 15 g of almonds, and 15 g of hazelnuts.<a href=\"#fn81\" class=\"footnote-ref\" id=\"fnref81\" role=\"doc-noteref\"><sup>81<\/sup><\/a> In cases of oligozoospermia, omega-3 fatty acids capsule supplementation (1 gram twice daily) for 3 months led to significant improvements in sperm count and total motile sperm count in 70 infertile men (age 20-45 years) with oligozoospermia. This study was limited by its small sample size due to time constraints, so generalizability is limited. Only one dose of omega-3 fatty acid was used in this study, so the effect of different doses of omega-3 on different sperm parameters could not be examined. Additionally, the side effects of taking omega-3 fatty acids were not evaluated.<a href=\"#fn82\" class=\"footnote-ref\" id=\"fnref82\" role=\"doc-noteref\"><sup>82<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There is significant variability in the results of studies on omega-3 supplementation, which may be due to differences in administration periods and\u00a0dosages. More standardized research is needed to confirm the optimal conditions for omega-3 supplementation in treating male infertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"dosage-recommendation-based-on-research-2\">Dosage Recommendation Based on Research<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The U.S. Food and Drug Administration recommends consuming\u00a0no more than 5 g\/day of omega-3 fatty acids from dietary supplements. The recommended dosage for omega-3 fatty acids is 1.1-1.8 g\/day for improving sperm count, morphology, motility, vitality, and sperm concentration.<a href=\"#fn83\" class=\"footnote-ref\" id=\"fnref83\" role=\"doc-noteref\"><sup>83<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Table 7 Dosage Recommendation of Omega-3 fatty acids for Adult Men (age more than 14 years)<\/strong><\/em><\/p>\n\n\n\n<div class=\"pcrstb-wrap\"><table>\n<colgroup>\n<col style=\"width: 14%\" \/>\n<col style=\"width: 27%\" \/>\n<col style=\"width: 24%\" \/>\n<col style=\"width: 17%\" \/>\n<col style=\"width: 15%\" \/>\n<\/colgroup>\n<thead>\n<tr class=\"header\">\n<th><strong>Nutrient<\/strong><\/th>\n<th><strong>Minimum daily recommended intake for adult men<\/strong><\/th>\n<th><strong>Daily Recommended Intake for better semen parameters<\/strong><\/th>\n<th><strong>Don\u2019t take more than<\/strong><\/th>\n<th><strong>When will I see results?<\/strong><\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Omega-3 fatty acids<\/th>\n<th>250-500 mg\/day<\/th>\n<th>1.1 to 1.8 g\/day for sperm count, morphology, vitality, motility, and sperm concentration<\/th>\n<th>5g\/day<\/th>\n<th>3 months<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<\/tbody>\n<\/table><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"food-sources-2\">Food Sources<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Plant sources that are rich in omega-3 fatty acids\u00a0are:<a href=\"#fn84\" class=\"footnote-ref\" id=\"fnref84\" role=\"doc-noteref\"><sup>84<\/sup><\/a><\/p>\n\n\n\n<ul>\n<li><p>Chia seeds: 5 g\/100 g<\/p><\/li>\n<li><p>Walnut: 2.5 g\/100 g<\/p><\/li>\n<li><p>Soybean: 0.67 g\/100 g<\/p><\/li>\n<li><p>Flaxseed oil: 7.2g\/tablespoon (13.6g)<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Animal sources that are rich in omega-3 fatty acids\u00a0are:<\/p>\n\n\n\n<ul>\n<li><p>Salmon: 2.2 g\/100 g<\/p><\/li>\n<li><p>Mackerel: 4.8 g\/100 g<\/p><\/li>\n<li><p>Cod liver oil: 2.4 g per tablespoon<\/p><\/li>\n<li><p>Smoked herring: 2.1g\/100g<\/p><\/li>\n<li><p>Raw oyster: 0.32g per 6 raw eastern oysters<\/p><\/li>\n<li><p>Canned Atlantic sardines: 1.46 g per cup (149 g)<\/p><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"side-effects-2\">Side Effects<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Common side effects: Side effects\u00a0of\u00a0omega-3 fatty acids\u00a0may include stomach pain, diarrhea, burping, or nausea.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Drug interaction: Omega-3 fatty acids may interact with medications such as antidiabetics, blood pressure regulators, and blood thinners.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Safety Precautions: Consult your healthcare\u00a0provider before taking\u00a0supplements.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"bottom-line-2\">Bottom Line<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Strength of recommendation: Research suggests that omega-3 fatty acids have high potential as a treatment to enhance male fertility by improving sperm quality (sperm concentration, count, morphology, vitality, and motility). This is supported by multiple studies showing that omega-3 supplementation can lead to better semen parameters in infertile men, although further research is still needed to establish its long-term effects, safety, and optimal dosing.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"specific-nutrient-antioxidants\">Specific Nutrient: Antioxidants<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-it-3\">What is it<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Antioxidants are compounds in food that\u00a0scavenge and neutralize free radicals or ROS from the body&#8217;s cells and protect from damage caused by oxidation. Certain nutrients possess antioxidant properties. Lycopene is a bright red natural pigment (carotenoid) mostly found in fruits and vegetables that are red in color. Lycopene is a powerful antioxidant.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L-carnitine, or 3-aminobutyric acid, is a naturally occurring amino acid derivative or a semi-essential vitamin that acts as a cofactor in bioenergetic processes and transports long-chain fatty acids from cytosol to mitochondria for energy production from fat.<a href=\"#fn85\" class=\"footnote-ref\" id=\"fnref85\" role=\"doc-noteref\"><sup>85<\/sup><\/a> Coenzyme Q (CoQ10), also known as ubiquinone, is a naturally occurring lipid-soluble strong antioxidant and cofactor (co-enzyme) that participates in bioenergetic processes and converts food into energy. It is usually naturally produced by the human body.<a href=\"#fn86\" class=\"footnote-ref\" id=\"fnref86\" role=\"doc-noteref\"><sup>86<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"how-it-works-3\">How it Works<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The ability of sperm to fertilize the egg is primarily dependent on sperm motility and membrane integrity. Sperm cells produce reactive oxygen species (ROS) and antioxidants in seminal plasma try to neutralize it. Excessive and uncontrolled production of ROS and oxidative stress is due to immature and damaged spermatozoa, infection, smoking, etc. This can damage sperm and impair the ability to fertilize an egg.\u00a0Antioxidants help neutralize the ROS that can damage sperm. Nutrients such as lycopene, coenzyme (CoQ10), and L-carnitine are powerful antioxidants that can counteract oxidative stress, improving sperm quality.<a href=\"#fn87\" class=\"footnote-ref\" id=\"fnref87\" role=\"doc-noteref\"><sup>87<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-the-research-is-telling-us-3\">What the Research is Telling us<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u00a0Studies have shown that lycopene can significantly improve male fertility.\u00a0In one study, one can of tomato juice consumption (30 mg lycopene) for three months improved sperm motility. However, no significant improvement was observed with the daily consumption of one antioxidant capsule (containing vitamin C 600 mg, vitamin E 200 mg, and glutathione 300 mg).<a href=\"#fn88\" class=\"footnote-ref\" id=\"fnref88\" role=\"doc-noteref\"><sup>88<\/sup><\/a> Similarly, a study on 44 infertile males with oligozoospermia (low sperm count) showed significantly increased ejaculate volume, sperm count, motility, and concentration when given a lycopene supplement (25 mg\/day) for 3 months.<a href=\"#fn89\" class=\"footnote-ref\" id=\"fnref89\" role=\"doc-noteref\"><sup>89<\/sup><\/a> While current studies show promising results, they often involve small sample sizes and short durations. Larger, long-term clinical trials are necessary to confirm the efficacy and optimal dosage of lycopene for treating male\u00a0infertility. In addition, further research is needed to explore whether lycopene affects hormonal levels, such as LH, FSH, estradiol, testosterone, and prolactin, which could provide additional insights into its role in male reproductive\u00a0health.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Many studies have demonstrated that L-carnitine can increase sperm motility and count, particularly in men with conditions like asthenozoospermia (low sperm motility) and oligozoospermia (low sperm count).\u00a0A study on 60 infertile males with asthenozoospermia, showed significantly improved sperm motility when given L-carnitine supplement (2g\/day) for 6 months.<a href=\"#fn90\" class=\"footnote-ref\" id=\"fnref90\" role=\"doc-noteref\"><sup>90<\/sup><\/a> In a similar study on 72 infertile men with asthenozoospermia, L-carnitine supplementation (660 mg\/day) for 3 months increased sperm motility.<a href=\"#fn91\" class=\"footnote-ref\" id=\"fnref91\" role=\"doc-noteref\"><sup>91<\/sup><\/a> Furthermore, a recent study has demonstrated that a daily dose of L-carnitine (2 g\/day) for 3 months can improve sperm concentration, sperm count, percentage of actively motile sperm, and progressively motile sperm count among men (134 patients) with idiopathic oligo- and\/or astheno-zoospermia (low sperm count and\/or abnormal sperm motility).<a href=\"#fn92\" class=\"footnote-ref\" id=\"fnref92\" role=\"doc-noteref\"><sup>92<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00a0CoQ10 supplementation has been shown to improve sperm quality in several studies.\u00a0A study of 65 infertile men with idiopathic oligoasthenoteratozoospermia (OAT) exhibited a notable increase in sperm concentration, progressive motility and total motility, and semen antioxidant capacity when treated with a CoQ10 oral supplement (200-400 mg\/day) for 3 months.<a href=\"#fn93\" class=\"footnote-ref\" id=\"fnref93\" role=\"doc-noteref\"><sup>93<\/sup><\/a> Similar results were observed in an identical study on 212 infertile men with idiopathic oligoasthenoteratozoospermia (OAT), where a CoQ10 oral supplement (300 mg\/day) for 3 months improved sperm quality (sperm motility, count, and morphology).<a href=\"#fn94\" class=\"footnote-ref\" id=\"fnref94\" role=\"doc-noteref\"><sup>94<\/sup><\/a> The optimal dosage of CoQ10 and its potential synergistic effects with other antioxidants remain areas for further research.\u00a0<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"dosage-recommendation-based-on-research-3\">Dosage Recommendation Based on Research<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The recommended dose of lycopene supplement ranges from 2-30 mg per day for up to six months to improve sperm motility.<a href=\"#fn95\" class=\"footnote-ref\" id=\"fnref95\" role=\"doc-noteref\"><sup>95<\/sup><\/a> A daily dose of 2 g of L-carnitine is safe for up to 12 months to improve sperm motility.<a href=\"#fn96\" class=\"footnote-ref\" id=\"fnref96\" role=\"doc-noteref\"><sup>96<\/sup><\/a> Standard dosages for CoQ10 supplements range between 60 and 500 milligrams daily for 3 months to increase sperm concentration, count, morphology, and motility.<a href=\"#fn97\" class=\"footnote-ref\" id=\"fnref97\" role=\"doc-noteref\"><sup>97<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Table 8 Dosage Recommendation of Certain Antioxidants for Adult Men (age more than 14 years)<\/strong><\/em><\/p>\n\n\n\n<div class=\"pcrstb-wrap\"><table>\n<colgroup>\n<col style=\"width: 14%\" \/>\n<col style=\"width: 20%\" \/>\n<col style=\"width: 27%\" \/>\n<col style=\"width: 18%\" \/>\n<col style=\"width: 18%\" \/>\n<\/colgroup>\n<thead>\n<tr class=\"header\">\n<th><strong>Nutrient<\/strong><\/th>\n<th><strong>Minimum daily recommended intake for adult men<\/strong><\/th>\n<th><strong>Daily recommended intake for better semen parameters<\/strong><\/th>\n<th><strong>Don\u2019t take more than<\/strong><\/th>\n<th><strong>When will I see results?<\/strong><\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Lycopene<\/th>\n<th>8-21 mg\/day<\/th>\n<th>2-30 mg\/day to improve sperm motility, ejaculate volume, sperm count, and concentration<\/th>\n<th>30 mg\/day<\/th>\n<th>12 weeks<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>L-carnitine<\/th>\n<th>15 mg\/day<\/th>\n<th>2 g\/day to improve sperm motility and count<\/th>\n<th>2 g\/day<\/th>\n<th>12 weeks<\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>CoQ10<\/th>\n<th>30-100 mg\/day<\/th>\n<th>60-500 mg\/day to enhance sperm concentration, count, morphology, and motility<\/th>\n<th>500 mg\/day<\/th>\n<th>12 weeks<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<\/tbody>\n<\/table><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"food-sources-3\">Food Sources<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Lycopene is primarily found in plant sources. Foods high in lycopene are:<a href=\"#fn98\" class=\"footnote-ref\" id=\"fnref98\" role=\"doc-noteref\"><sup>98<\/sup><\/a><\/p>\n\n\n\n<ul>\n<li><p>Guavas: 5.2 mg\/100 g<\/p><\/li>\n<li><p>Tomato (cooked): 7.2 mg per cup<\/p><\/li>\n<li><p>Watermelon: 4.5 mg\/100g<\/p><\/li>\n<li><p>Grapefruit: 1.4 mg\/100g<\/p><\/li>\n<li><p>Papaya: 1.8 mg\/100g<\/p><\/li>\n<li><p>Red bell pepper: 0.513 mg per cup cooked<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Plant sources rich in L-carnitine are:<a href=\"#fn99\" class=\"footnote-ref\" id=\"fnref99\" role=\"doc-noteref\"><sup>99<\/sup><\/a><\/p>\n\n\n\n<ul>\n<li><p>Cooked asparagus: 0.1 mg per half cup, 0.02% of DV<\/p><\/li>\n<li><p>Avocado: 2 mg per medium-sized avocado<\/p><\/li>\n<li><p>Animal sources rich in L-carnitine are:<\/p><\/li>\n<li><p>Cooked beef steak: 56-162 mg\/113g, 11.2% to 32% of DV<\/p><\/li>\n<li><p>Cooked ground beef: 65-74 mg\/85g, 13% to 15% of DV<\/p><\/li>\n<li><p>Cooked pork meat: 42 mg\/113g, 8.4% of DV<\/p><\/li>\n<li><p>Milk: 8-12 mg\/240 ml, 2% of DV<\/p><\/li>\n<li><p>Hard cheese: 3 mg\/100g, 0.6% of DV<\/p><\/li>\n<li><p>Cooked chicken breast: 2-4 mg\/85g, 0.4-0.8% of DV<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Plant sources abundant in CoQ10 are:<\/p>\n\n\n\n<ul>\n<li><p>Boiled soybean: 1.2 mg\/100g<\/p><\/li>\n<li><p>Pistachio: 2 mg\/100g<\/p><\/li>\n<li><p>Peanut: 2.6 mg\/100g<\/p><\/li>\n<li><p>Broccoli: 0.6-0.86 mg\/100g<\/p><\/li>\n<li><p>Sesame seeds: 1.7 mg\/100g<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Animal sources abundant in CoQ10 are:<\/p>\n\n\n\n<ul>\n<li><p>Beef: 3.1 mg\/100g<\/p><\/li>\n<li><p>Mackerel fish: 6.75 mg\/100g<\/p><\/li>\n<li><p>Trout: 0.85mg\/100g<\/p><\/li>\n<li><p>Chicken:1.4 mg\/100g<\/p><\/li>\n<li><p>Pork:2.4 mg\/100g<\/p><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"side-effects-3\">Side Effects<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Common side effects: Lycopene is generally safe. A daily dose of 2 g of L-carnitine is safe but may have mild side effects like heartburn and indigestion.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CoQ10 may cause side effects like nausea, diarrhea, heartburn, and abdominal pain.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Drug interactions: Lycopene may interfere with medications such as anticoagulants or antiplatelet drugs. L-carnitine may interfere with medications such as anticoagulants and thyroid medication. CoQ10 may interfere with medications such as anticoagulants, antidiabetics, and thyroid medication.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Safety Precautions: Talk to your\u00a0doctor before\u00a0adding\u00a0supplements\u00a0to your diet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"bottom-line-3\">Bottom Line<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Strength of recommendations: Lycopene appears to be a promising agent for improving sperm quality (sperm motility, ejaculate volume, sperm count, and concentration). However, larger, long-term clinical trials are necessary to confirm the efficacy and optimal dosage of lycopene for treating male\u00a0infertility.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L-carnitine shows promise as a treatment for male infertility by improving sperm motility and count. Likewise, CoQ10 was found to be effective in improving sperm concentration, count, morphology, and motility. However, there is a need for larger, well-designed clinical trials to better understand the clinical efficacy of L-carnitine and CoQ10 in treating male infertility and to establish standardized treatment\u00a0protocols.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"specific-nutrient-amino-acids\">Specific Nutrient: Amino acids<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-it-4\">What is it<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Amino acids are organic compounds that are involved in protein synthesis, which is essential for producing sperm and reproductive hormones. D-Aspartic acid is a non-essential amino acid that is naturally produced by the human body. L-arginine is a conditionally essential amino acid that plays a crucial role in protein buildup and blood circulation. It must be obtained through diet during certain conditions such as stress or illness.<a href=\"#fn100\" class=\"footnote-ref\" id=\"fnref100\" role=\"doc-noteref\"><sup>100<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"how-it-works-4\">How it Works<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">D-aspartic acid occurs mainly in the pituitary gland and testes\u00a0and regulates the synthesis and secretion of reproductive hormones like testosterone.<a href=\"#fn101\" class=\"footnote-ref\" id=\"fnref101\" role=\"doc-noteref\"><sup>101<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L-arginine induces the synthesis and release of nitric oxide, leading to higher testicular blood flow and improved testosterone production by the testes. Nitric oxide has an important role in regulating sperm capacitation and the acrosome reaction, hence improving sperm&#8217;s ability to fertilize an egg.<sup>100<\/sup><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-the-research-is-telling-us-4\">What the Research is Telling us<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">D-aspartic acid plays a direct role in enhancing the capacitation process and acrosome reaction of spermatozoa, which are essential steps for successful fertilization. This effect has been particularly noted in younger mice, where D-aspartic acid treatment significantly increased these\u00a0parameters. In an animal study based on a mouse model, a D-aspartic acid oral supplement for 2 weeks improved fertilizing capacity and sperm quality and increased testosterone levels.<a href=\"#fn102\" class=\"footnote-ref\" id=\"fnref102\" role=\"doc-noteref\"><sup>102<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A human study on 30 male patients with oligoasthenozoospermia and 30 male patients with asthenozoospermia demonstrated a notable increase in sperm concentration and motility and eventual rate of pregnancy when provided oral supplementation of sodium D-aspartate (2.6 g\/day) for 3 months. In the case of oligoasthenozoospermia patients, there was a two-fold increase in sperm concentration.<a href=\"#fn103\" class=\"footnote-ref\" id=\"fnref103\" role=\"doc-noteref\"><sup>103<\/sup><\/a> D-aspartic acid has been shown to increase sperm motility, concentration, and testosterone levels in both animal models and human\u00a0studies. However, the long-term effects and safety of D-aspartic acid supplementation need further investigation to ensure its efficacy and safety for prolonged use in fertility\u00a0treatments.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Some studies have demonstrated that L-arginine supplementation can improve various parameters of sperm quality in men. L-arginine oral supplement (1000 mg\/day) for 4 months showed a positive effect on sperm count, morphology, progressive motility, and ejaculate volume in a study on 15 infertile men.<a href=\"#fn104\" class=\"footnote-ref\" id=\"fnref104\" role=\"doc-noteref\"><sup>104<\/sup><\/a> In another study on 540 patients with erectile dysfunction, due to its vasodilating property, L-arginine supplement (1500-5000 mg) for 3 months helped in restoring erectile function.<a href=\"#fn105\" class=\"footnote-ref\" id=\"fnref105\" role=\"doc-noteref\"><sup>105<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"dosage-recommendation-based-on-research-4\">Dosage Recommendation Based on Research<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">D-aspartic acid is possibly safe when used in doses of 2.6 to 3 grams daily for up to 3 months to increase testosterone levels, sperm concentration, and motility. L-arginine dose should be kept between 1 to 5 grams daily for up to 3 months to enhance erectile function, sperm count, sperm motility, morphology, and ejaculate volume.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Table 9 Dosage Recommendation of Certain Amino acids for Adult Men (age more than 14 years)<\/strong><\/em><\/p>\n\n\n\n<div class=\"pcrstb-wrap\"><table>\n<colgroup>\n<col style=\"width: 14%\" \/>\n<col style=\"width: 21%\" \/>\n<col style=\"width: 28%\" \/>\n<col style=\"width: 18%\" \/>\n<col style=\"width: 18%\" \/>\n<\/colgroup>\n<thead>\n<tr class=\"header\">\n<th>Nutrient<\/th>\n<th>Minimum daily recommended intake for adult men<\/th>\n<th>Daily recommended intake for better semen parameters<\/th>\n<th>Don\u2019t take more than<\/th>\n<th>When will I see results?<\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>D-aspartic acid<\/th>\n<th>2-3 g\/day<\/th>\n<th>2.6 g\/day months to increase testosterone levels, sperm concentration, and motility<\/th>\n<th>6g \/day<\/th>\n<th>12 weeks<\/th>\n<\/tr>\n<tr class=\"header\">\n<th>L-arginine<\/th>\n<th>_<\/th>\n<th>1-5g\/day to enhance erectile function, sperm count, sperm motility, morphology, and ejaculate volume<\/th>\n<th>5 g\/day<\/th>\n<th>12 weeks<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<\/tbody>\n<\/table><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"food-sources-4\">Food Sources<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Plant sources rich in D-aspartic acid are:<a href=\"#fn106\" class=\"footnote-ref\" id=\"fnref106\" role=\"doc-noteref\"><sup>106<\/sup><\/a><\/p>\n\n\n\n<ul>\n<li><p>Avocado: 474 mg per fruit.<\/p><\/li>\n<li><p>Nectarine: 886 mg per fruit<\/p><\/li>\n<li><p>Asparagus: 500 mg per half cup of cooked asparagus<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Animal sources rich in D-aspartic acid are:<\/p>\n\n\n\n<ul>\n<li><p>Beef steak (cooked): 2809 mg per 85 g,<\/p><\/li>\n<li><p>Chicken breast (cooked): 2563 mg per 3 ounces<\/p><\/li>\n<li><p>Egg (hard-boiled): 632 mg per egg<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Plant sources that are naturally rich in L-arginine are:<a href=\"#fn107\" class=\"footnote-ref\" id=\"fnref107\" role=\"doc-noteref\"><sup>107<\/sup><\/a><\/p>\n\n\n\n<ul>\n<li><p>Peanut: 3.35 g\/100g<\/p><\/li>\n<li><p>Pumpkin seed: 5.35 g\/100g<\/p><\/li>\n<li><p>Soy protein concentrate: 4.64 g\/100g<\/p><\/li>\n<li><p>Walnut: 3.62 g\/100g<\/p><\/li>\n<li><p>Sesame: 3.25 g \/100g<\/p><\/li>\n<li><p>Tofu: 3.19 g\/100g<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Animal sources that are naturally rich in L-arginine are:<\/p>\n\n\n\n<ul>\n<li><p>One cooked turkey breast:16 g of L-arginine<\/p><\/li>\n<li><p>One cooked chicken breast: 9 g of L-arginine<\/p><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"side-effects-4\">Side Effects<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Common side effects: D-aspartic acid supplements can cause side effects such as\u00a0irritability, anxiety, and headache.<a href=\"#fn108\" class=\"footnote-ref\" id=\"fnref108\" role=\"doc-noteref\"><sup>108<\/sup><\/a> L-arginine supplements can cause \u00a0stomach pain, diarrhea, low blood pressure, and bloating.<a href=\"#fn109\" class=\"footnote-ref\" id=\"fnref109\" role=\"doc-noteref\"><sup>109<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Drug interactions: D-aspartic acid may interfere with medications such as antidepressants and seizure medications. L-arginine may interact with medications like antidiabetics, sildenafil, blood pressure regulators, and anticoagulants.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Safety Precautions: Seek advice from a healthcare\u00a0provider before taking\u00a0supplements.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"bottom-line-4\">Bottom Line<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Strength of recommendations: D-aspartic acid shows promise as a treatment to enhance male fertility by improving sperm quality (sperm concentration and motility) and hormonal balance (increase testosterone levels) in both animal and human models. Clinical studies have reported improvements in sperm motility and overall semen parameters (sperm count, morphology, and ejaculate volume) with the use of L-arginine.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">While the benefits of D-aspartic acid and L-arginine are evident, determining the optimal dosage and treatment duration for human subjects remains a challenge. Further research is needed to establish standardized treatment\u00a0protocols.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"specific-nutrient-spermidine\">Specific Nutrient: Spermidine<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-it-5\">What is it<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Spermidine is a polyamine, or biogenic amine, found in ribosomes and living tissues. It got its name due to its isolation from seminal fluid for the first time in 1870. It is naturally present in various foods and is synthesized in the human body. Human seminal plasma contains spermidine, which is found in high concentrations within this fluid. Spermidine is considered one of the key components of seminal plasma, playing a role in sperm function and maintaining the alkaline pH of semen.\u00a0The average concentration of spermidine in human seminal plasma is 31 mg\/L, but it can range from 15 to 50 mg\/ml. <a href=\"#fn110\" class=\"footnote-ref\" id=\"fnref110\" role=\"doc-noteref\"><sup>110<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"how-it-works-5\">How it Works<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Spermidine is implicated in the process of spermatogenesis (the production of sperm), which is essential for male fertility. Metabolomic analyses have identified spermidine as a vital component in seminal plasma, indicating its role in the development and function of sperm cells. This suggests that spermidine could be crucial in maintaining or improving sperm quality, which is often compromised in cases of male\u00a0infertility.<a href=\"#fn111\" class=\"footnote-ref\" id=\"fnref111\" role=\"doc-noteref\"><sup>111<\/sup><\/a> Spermidine has anti-inflammatory and antioxidant potential. Dietary intake of spermidine has a positive impact on semen parameters. Spermidine protects sperm from oxidative damage, reduces cortisol levels (stress hormone level), and increases testosterone levels.<a href=\"#fn112\" class=\"footnote-ref\" id=\"fnref112\" role=\"doc-noteref\"><sup>112<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-the-research-is-telling-us-5\">What the Research is Telling us<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A study involving 15 healthy men with no history of infertility or sexual dysfunction showed a 48.9% significant increase in testosterone levels and a 58% reduction in cortisol levels with supplementation of spermidine (the dosage amount was not provided) for 30 days. For both fertility and sexual performance, it is important to reduce cortisol levels.<sup>112<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In an animal study on diabetic mice, spermidine treatment improved spermatogenic cell proliferation and testicular function and increased testis weight and sperm count.<a href=\"#fn113\" class=\"footnote-ref\" id=\"fnref113\" role=\"doc-noteref\"><sup>113<\/sup><\/a> Despite promising findings, the evidence on spermidine&#8217;s supplement effectiveness in improving male fertility is still emerging. Most studies emphasize the need for larger, well-designed trials to confirm these initial results and to better understand the specific role of spermidine among other\u00a0nutrients.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"dosage-recommendation-based-on-research-5\">Dosage Recommendation Based on Research<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The average daily intake of spermidine in supplement form ranged from\u00a04.8 to 17.0 mg\/day.<a href=\"#fn114\" class=\"footnote-ref\" id=\"fnref114\" role=\"doc-noteref\"><sup>114<\/sup><\/a> A daily dose of 5-10 mg spermidine supplement is safe to improve testosterone levels and reduce cortisol levels. No known side effects are there for high doses.<a href=\"#fn115\" class=\"footnote-ref\" id=\"fnref115\" role=\"doc-noteref\"><sup>115<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Table 10 Dosage Recommendation for Spermidine<\/strong><\/em><\/p>\n\n\n\n<div class=\"pcrstb-wrap\"><table>\n<colgroup>\n<col style=\"width: 14%\" \/>\n<col style=\"width: 19%\" \/>\n<col style=\"width: 27%\" \/>\n<col style=\"width: 17%\" \/>\n<col style=\"width: 20%\" \/>\n<\/colgroup>\n<thead>\n<tr class=\"header\">\n<th><strong>Nutrient<\/strong><\/th>\n<th><strong>Minimum daily recommended intake for adult men<\/strong><\/th>\n<th><strong>Daily recommended intake for better semen parameters<\/strong><\/th>\n<th><strong>Don\u2019t take more than<\/strong><\/th>\n<th><strong>When will I see results?<\/strong><\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Spermidine<\/th>\n<th>1-6 mg\/day<\/th>\n<th>5-10 mg\/day to improve testosterone levels and reduce cortisol levels<\/th>\n<th>g \/day<\/th>\n<th>Weeks<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<\/tbody>\n<\/table><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"food-sources-5\">Food Sources<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Plant sources high in spermidine include:<a href=\"#fn116\" class=\"footnote-ref\" id=\"fnref116\" role=\"doc-noteref\"><sup>116<\/sup><\/a><\/p>\n\n\n\n<ul>\n<li><p>Mango: 3 mg\/100g<\/p><\/li>\n<li><p>Wheat germ: 243 mg\/100 g<\/p><\/li>\n<li><p>Hazelnut: 2.1 mg\/100 g<\/p><\/li>\n<li><p>Soybean: 20.7 mg\/100g<\/p><\/li>\n<li><p>Mushroom: 8.8 mg\/100 g<\/p><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Animal sources high in spermidine include:<\/p>\n\n\n\n<ul>\n<li><p>Chicken liver: 4.8 mg\/100 g<\/p><\/li>\n<li><p>Beef: 3.7 mg\/100 g<\/p><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"side-effects-5\">Side Effects<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Common side effects: There are no known side effects for high doses of spermidine.<a href=\"#fn117\" class=\"footnote-ref\" id=\"fnref117\" role=\"doc-noteref\"><sup>117<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Drug interaction: Spermidine may interact with medications such as antidepressants and blood thinners.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Safety Precautions: Please consult a physician before taking it.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"bottom-line-5\">Bottom Line<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Strength of recommendation: Spermidine has shown potential in improving fertility by increasing testosterone levels and reducing stress. However, more extensive research is needed to fully understand its benefits and explore the optimal dosage and duration of spermidine supplementation for fertility\u00a0benefits.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"specific-nutrient-ashwagandha\">Specific Nutrient: Ashwagandha<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-it-6\">What is it<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Ashwagandha (<em>Withania somnifera<\/em>) is an aphrodisiac and adaptogenic evergreen herb found in India, northern Africa, and the Middle East. It has been used for more than 6,000 years in Ayurveda, one of the world&#8217;s oldest\u00a0studies of natural healing practiced in India.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"how-it-works-6\">How it Works<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The principal\u00a0bioactive compounds\u00a0of ashwagandha are triterpene lactones known as withanolides. Withanolides\u00a0have antioxidant, antistress, and anti-inflammatory properties. It protects spermatozoa from oxidative stress and increases libido by lowering stress hormone (cortisol) levels. Ashwagandha increases testosterone levels and balances hormones.<a href=\"#fn118\" class=\"footnote-ref\" id=\"fnref118\" role=\"doc-noteref\"><sup>118<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-the-research-is-telling-us-6\">What the Research is Telling us<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A study involving 46 male patients with oligospermia (sperm count less than 20\u2009million\/ml semen) observed a 167% significant increase in sperm count, 53% increase in semen volume, and 57% increase in sperm motility with supplementation of ashwagandha root extract (675 mg\/day in three doses) for 90 days. Furthermore, a significantly greater improvement and regulation were observed in serum hormone levels. Serum testosterone level was markedly increased by 17% and LH by 34%.<sup>118<\/sup> Research on 30 men (aged 18-45 years) with semen disorder (low sperm count or motility) showed that daily oral supplementation of one capsule (one gram of concentrated ashwagandha powder) 5 times a day for 3 months enhanced sperm concentration and motility. <a href=\"#fn119\" class=\"footnote-ref\" id=\"fnref119\" role=\"doc-noteref\"><sup>119<\/sup><\/a> These studies add to the evidence of the therapeutic value of Ashwagandha as attributed in Ayurveda for the treatment of infertility.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">While Ashwagandha shows promise, more studies are needed to determine the optimal dosage and to ensure its safety as a treatment for male infertility. Current evidence suggests it is beneficial, but comprehensive toxicological studies are\u00a0lacking.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"dosage-recommendation-based-on-research-6\">Dosage Recommendation Based on Research<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The recommended dosage for ashwagandha ranges from 300 mg to 600 mg\/day for 1-2 months to increase semen volume, sperm count, and motility.<a href=\"#fn120\" class=\"footnote-ref\" id=\"fnref120\" role=\"doc-noteref\"><sup>120<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Table 11 Dosage Recommendation for Ashwagandha<\/strong><\/em><\/p>\n\n\n\n<div class=\"pcrstb-wrap\"><table>\n<colgroup>\n<col style=\"width: 18%\" \/>\n<col style=\"width: 20%\" \/>\n<col style=\"width: 27%\" \/>\n<col style=\"width: 17%\" \/>\n<col style=\"width: 17%\" \/>\n<\/colgroup>\n<thead>\n<tr class=\"header\">\n<th><strong>Nutrient<\/strong><\/th>\n<th><strong>Minimum daily recommended intake for adult men<\/strong><\/th>\n<th><strong>Daily recommended intake for better semen parameters<\/strong><\/th>\n<th><strong>Don\u2019t take more than<\/strong><\/th>\n<th><strong>When will I see results?<\/strong><\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Ashwagandha<\/th>\n<th>_<\/th>\n<th>300-600 mg\/day to increase semen volume, sperm count, and motility<\/th>\n<th>5 g \/day<\/th>\n<th>1-2 months<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<\/tbody>\n<\/table><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"side-effects-6\">Side Effects<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Common side effects: Side effects\u00a0of\u00a0ashwagandha\u00a0may include diarrhea, headache, sedation, nausea, or liver problems.<a href=\"#fn121\" class=\"footnote-ref\" id=\"fnref121\" role=\"doc-noteref\"><sup>121<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Drug interactions: Ashwagandha may interact or interfere with medications such as antidiabetics, antihistamines, antihyperglycemic, contraceptives, thyroid hormone supplements, immunosuppressants, blood pressure regulators, and blood thinners.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Safety Precautions: Seek an opinion from your doctor before taking\u00a0 this herbal supplement.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"bottom-line-6\">Bottom Line<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Strength of recommendations: Ashwagandha appears to be a promising herbal remedy for improving male fertility by enhancing sperm quality (sperm count, motility, semen volume) and regulating hormones. However, further research is necessary to fully understand its mechanisms and to establish standardized treatment protocols.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"specific-nutrient-maca\">Specific Nutrient: Maca<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-it-7\">What is it<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Maca (<em>Lepidium meyenii<\/em>), also known as Peruvian Ginseng or Ginseng Andin, is a herbaceous plant that originated in Peru.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"how-it-works-7\">How it Works<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Maca root is rich in a unique bioactive compound known as macamides that possess antioxidant, anti-inflammatory, and libido and sperm quality-enhancing properties.<a href=\"#fn122\" class=\"footnote-ref\" id=\"fnref122\" role=\"doc-noteref\"><sup>122<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-the-research-is-telling-us-7\">What the Research is Telling us<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u00a0Research on 20 healthy adult men men (aged 20-40 years) showed that daily oral supplementation of milled hypocotyl\u00a0maca (1.75 g\/day) for 3 months enhanced sperm concentration and motility with no significant change in hormone levels.<sup>122<\/sup> Another study on 9 adult men (aged 24-44 years) showed that daily oral supplementation of maca tablets (1.5 to 3 g\/day) for 4 months increased ejaculate volume, sperm count, and motility. However, no change in serum hormone levels (LH, FSH, testosterone, prolactin, and estradiol) was observed with Maca treatment.<a href=\"#fn123\" class=\"footnote-ref\" id=\"fnref123\" role=\"doc-noteref\"><sup>123<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Maca root oral supplementation capsule (2.8 g\/day divided into 7 doses) for 3 months did not show significant improvement in sperm concentration and hormone levels (LH, FSH, testosterone, and estradiol) in 50 patients suffering from various reproductive-related problems. Maca root supplement was gelatinized and powdered dried bulb of yellow maca having less than 7% humidity.<a href=\"#fn124\" class=\"footnote-ref\" id=\"fnref124\" role=\"doc-noteref\"><sup>124<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Research indicates that maca does not significantly alter serum reproductive hormone levels in men. Studies have shown no effect on hormones such as testosterone, luteinizing hormone, and follicle-stimulating hormone when maca is\u00a0administered. This suggests that any potential fertility benefits of maca are not mediated through changes in hormone levels.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Small sample sizes and methodological inconsistencies limit the current research on maca&#8217;s effects on male infertility. The evidence remains inconclusive, and more rigorous, large-scale studies are needed to determine the efficacy and safety of maca as a treatment for male\u00a0infertility.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"dosage-recommendation-based-on-research-7\">Dosage Recommendation Based on Research<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The recommended daily dose of maca ranges from\u00a01.5 to 3 g\/day for 4 months to increase ejaculate volume, sperm count, and motility.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Table 12 Dosage Recommendation for Maca<\/strong><\/em><\/p>\n\n\n\n<div class=\"pcrstb-wrap\"><table>\n<colgroup>\n<col style=\"width: 13%\" \/>\n<col style=\"width: 21%\" \/>\n<col style=\"width: 28%\" \/>\n<col style=\"width: 18%\" \/>\n<col style=\"width: 18%\" \/>\n<\/colgroup>\n<thead>\n<tr class=\"header\">\n<th><strong>Nutrient<\/strong><\/th>\n<th><strong>Minimum daily recommended intake for adult men<\/strong><\/th>\n<th><strong>Daily recommended intake for better semen parameters<\/strong><\/th>\n<th><strong>Don\u2019t take more than<\/strong><\/th>\n<th><strong>When will I see results?<\/strong><\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Maca<\/th>\n<th>_<\/th>\n<th>1.5-3 g\/day to increase ejaculate volume, sperm count, and motility<\/th>\n<th>3 g\/day<\/th>\n<th>4 months<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<\/tbody>\n<\/table><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"side-effects-7\">Side Effects<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Common side effects: Maca root has mild side effects like\u00a0headaches, stomach issues, insomnia, or jitteriness.<a href=\"#fn125\" class=\"footnote-ref\" id=\"fnref125\" role=\"doc-noteref\"><sup>125<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Drug interactions: People taking blood thinners, high blood pressure medicine, or having thyroid problems should take the advice of their healthcare provider.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Safety Precautions: Seek an opinion from your doctor before taking\u00a0herbal supplements.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"bottom-line-7\">Bottom Line<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Strength of recommendations: While maca root shows some promise in improving semen parameters (ejaculate volume, sperm count, and motility), the scientific evidence is not yet robust enough to support its widespread use for male infertility. Further research is necessary to clarify its potential benefits and mechanisms of action.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"specific-nutrient-red-ginseng\">Specific Nutrient: Red Ginseng<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-it-8\">What is it<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Red Ginseng (<em>Panax ginseng<\/em>) is a plant native to South Korea and China. Its roots have been used in traditional Chinese medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"how-it-works-8\">How it Works<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Red ginseng is one of the famous aphrodisiacs. It contains ginsenoside, a bioactive compound that has antioxidant and anti-inflammatory properties. Ginsenosides protect sperm cells from damage caused by free radicals.\u00a0Ginsenosides may impact the hypothalamus-pituitary-gonadal axis, stimulating the production of hormones like testosterone and FSH required for spermatogenesis and sexual vitality.<a href=\"#fn126\" class=\"footnote-ref\" id=\"fnref126\" role=\"doc-noteref\"><sup>126<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-the-research-is-telling-us-8\">What the Research is Telling us<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u00a0Red ginseng oral supplementation (1.5 g\/day) for 3 months was revealed to significantly improve motility, concentrations, morphology, and viability of sperm in 80 infertile men. However, there were no significant differences in hormone levels, i.e., serum FSH, LH, and testosterone. These patients were suffering from varicocele, an enlargement of the veins in the scrotum, that caused infertility.<sup>126<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In animal studies, red ginseng has been found to protect against testicular damage induced by various stressors. In experimental rat models, red ginseng ameliorated testicular damage caused by chronic intermittent heat stress and sub-acute immobilization stress. It improved sperm kinematics, restored organ weights, and modulated the expression of antioxidant enzymes and spermatogenesis-related\u00a0genes. These findings suggest that red ginseng may help mitigate stress-related male infertility.<a href=\"#fn127\" class=\"footnote-ref\" id=\"fnref127\" role=\"doc-noteref\"><sup>127<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Despite the promising findings, the exact mechanisms by which red ginseng improves male fertility are not fully understood, and further research is needed to determine the optimal dosage and duration of\u00a0treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"dosage-recommendation-based-on-research-8\">Dosage Recommendation Based on Research<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Red ginseng is safe for healthy adults to consume daily at a dose of 2\u00a0g for up to 3 months for improved motility, concentration, morphology, and viability of sperm.<a href=\"#fn128\" class=\"footnote-ref\" id=\"fnref128\" role=\"doc-noteref\"><sup>128<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Table 13 Dosage Recommendation for Red Ginseng<\/strong><\/em><\/p>\n\n\n\n<div class=\"pcrstb-wrap\"><table>\n<colgroup>\n<col style=\"width: 15%\" \/>\n<col style=\"width: 20%\" \/>\n<col style=\"width: 27%\" \/>\n<col style=\"width: 17%\" \/>\n<col style=\"width: 18%\" \/>\n<\/colgroup>\n<thead>\n<tr class=\"header\">\n<th><strong>Nutrient<\/strong><\/th>\n<th><strong>Minimum daily recommended intake for adult men<\/strong><\/th>\n<th><strong>Daily recommended intake for better semen parameters<\/strong><\/th>\n<th><strong>Don\u2019t take more than<\/strong><\/th>\n<th><strong>When will I see results?<\/strong><\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Red ginseng<\/th>\n<th>200 mg\/day<\/th>\n<th>2 g\/day for sperm motility, concentrations, morphology, and viability<\/th>\n<th>2 g\/day<\/th>\n<th>3 months<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<\/tbody>\n<\/table><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"side-effects-8\">Side Effects<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Common Side Effects: Side effects\u00a0of\u00a0red ginseng may include diarrhea, headache, increased blood pressure, nausea, or insomnia.<a href=\"#fn129\" class=\"footnote-ref\" id=\"fnref129\" role=\"doc-noteref\"><sup>129<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Drug Interactions: Red ginseng may interact or interfere with medications such as antidiabetics, antidepressants, antihypertensives, diuretics, and blood thinners.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Safety Precautions: Talk with your healthcare\u00a0provider before taking\u00a0herbal supplements.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"bottom-line-8\">Bottom Line<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Strength of recommendations: Red ginseng shows potential as a therapeutic agent for improving male fertility by improving motility, concentrations, morphology, and viability of sperm. However, further research with a focus on larger, well-designed studies is required to fully understand its mechanisms and to validate its clinical use.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"specific-nutrient-puncturevine\">Specific Nutrient: Puncturevine<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-it-9\">What is it<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Puncturevine (<em>Tribulus terrestris<\/em>), commonly called bindii or lawnweed,\u00a0is an annual herb, native to Africa, Asia, Australia, and Europe. It is an integral part of indigenous medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"how-it-works-9\">How it Works<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Puncturevine contains a strong phytochemical agent named protodioscin (steroidal saponin). Protodioscin acts on Sertoli cells, germ cell proliferation, and the growth of seminiferous tubules. Protodioscin is known to convert testosterone into dihydrotestosterone and acts as a stimulator of testosterone production, which plays an important role in male attributes. Dihydrotestosterone is\u00a0a hormone that stimulates the development of male sexual characteristics (an androgen) and is involved in the growth and repair of the prostate and the penis. Almost 10% of the testosterone produced by an adult each day is converted to dihydrotestosterone. It also acts as an antioxidant to protect sperm cells from oxidative damage. <a href=\"#fn130\" class=\"footnote-ref\" id=\"fnref130\" role=\"doc-noteref\"><sup>130<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-the-research-is-telling-us-9\">What the Research is Telling us<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In a study involving 65 men with abnormal semen evaluation, the oral administration of Androsten\u00ae (250 mg of puncturevine dried extract per capsule) was found to be effective in increasing testosterone levels, sperm concentration, and motility in a 90-day study. Also, a significant decrease in the percentage of body fat and an increase in lean mass were observed.<sup>130<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, no statistically significant difference was observed in the levels of testosterone (total and free) and LH and semen parameters (sperm concentration or motility, or abnormal forms) before and after the treatment with puncturevine supplementation (750 mg\/day in 3 divided doses) for 3 months in patients having idiopathic infertility. <a href=\"#fn131\" class=\"footnote-ref\" id=\"fnref131\" role=\"doc-noteref\"><sup>131<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In an animal study on a mouse model, the safety of puncturevine extract was evaluated for 28 days. The findings suggested that puncturevine does not adversely affect body weight, reproductive organ weights, or androgen-dependent biochemical\u00a0markers. <a href=\"#fn132\" class=\"footnote-ref\" id=\"fnref132\" role=\"doc-noteref\"><sup>132<\/sup><\/a>However, further research, particularly well-designed clinical trials with large population sizes, is needed to establish its role in treating male infertility conclusively.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"dosage-recommendation-based-on-research-9\">Dosage Recommendation Based on Research<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Puncturevine extract is possibly safe when taken at a dosage of 250-1500 mg\/day for up to 90 days for increasing testosterone levels, sperm concentration, and motility.<a href=\"#fn133\" class=\"footnote-ref\" id=\"fnref133\" role=\"doc-noteref\"><sup>133<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em><strong>Table 14 Dosage Recommendation for Puncturevine<\/strong><\/em><\/p>\n\n\n\n<div class=\"pcrstb-wrap\"><table>\n<colgroup>\n<col style=\"width: 15%\" \/>\n<col style=\"width: 20%\" \/>\n<col style=\"width: 27%\" \/>\n<col style=\"width: 18%\" \/>\n<col style=\"width: 17%\" \/>\n<\/colgroup>\n<thead>\n<tr class=\"header\">\n<th><strong>Nutrient<\/strong><\/th>\n<th><strong>Minimum daily recommended intake for adult men<\/strong><\/th>\n<th><strong>Daily recommended intake for better semen parameters<\/strong><\/th>\n<th><strong>Don\u2019t take more than<\/strong><\/th>\n<th><strong>When will I see results?<\/strong><\/th>\n<\/tr>\n<tr class=\"odd\">\n<th>Puncturevine<\/th>\n<th>_<\/th>\n<th>250-1500 mg\/day for increasing testosterone levels, sperm concentration, and motility<\/th>\n<th>1500 mg\/day<\/th>\n<th>3 months<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<\/tbody>\n<\/table><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"side-effects-9\">Side Effects<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Common Side Effects: The common side effects\u00a0of\u00a0puncturevine may include diarrhea, constipation, headache, increased blood pressure, nausea, or insomnia.<sup>133<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Drug Interactions: Puncturevine may interact with medications like antidiabetics, anti-hypertensives, diuretics, and blood thinners.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Safety Precautions: Speak with your healthcare\u00a0provider before taking\u00a0herbal supplements.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"bottom-line-9\">Bottom Line<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Strength of recommendations: Despite the promising results of puncturevine in improving testosterone levels, sperm concentration, and motility, its role in treating male infertility remains controversial. Some studies suggest its benefits, while others call for more rigorous, placebo-controlled trials to confirm its efficacy and better understand its mechanisms. Future research should focus on larger, well-designed studies to provide more definitive conclusions about its role in male infertility treatment.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"multi-nutrients\">Multi-Nutrients<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">A varied and balanced diet, including vegetables, fruits, fish, seafood, nuts, seeds, poultry, and low-fat dairy products, provides all the essential nutrients required for reproductive health. Fruits and vegetables are great sources of vital nutrients like antioxidants, minerals, vitamins, and other phytochemicals. A study based on a 3-day record method on 90 men suggested that men who consumed fruits and vegetables (&gt;734 g\/day) showed the highest sperm concentration, vitality, motility, and antioxidant capacity in semen and blood.<a href=\"#fn134\" class=\"footnote-ref\" id=\"fnref134\" role=\"doc-noteref\"><sup>134<\/sup><\/a> However, the fruits and vegetables should be organic and properly washed with water to remove pesticide residue since it has a detrimental effect on semen quality.<a href=\"#fn135\" class=\"footnote-ref\" id=\"fnref135\" role=\"doc-noteref\"><sup>135<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Some studies have highlighted the protective role of some fruit juices and extracts on male fertility in animal models. For instance, broccoli extract (300 mg\/kg) was found to improve testicular structure, sperm count, viability, motility, and serum and testes oxidative stress biomarkers, and increase testosterone levels in a mice model.<a href=\"#fn136\" class=\"footnote-ref\" id=\"fnref136\" role=\"doc-noteref\"><sup>136<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Protein provides the amino acids that are the building blocks of sperm cells. A low-protein diet can reduce the size and weight of the testicles and lower testosterone levels.<a href=\"#fn137\" class=\"footnote-ref\" id=\"fnref137\" role=\"doc-noteref\"><sup>137<\/sup><\/a> In a study on 270 infertile men, a diet rich in plant proteins was found to improve semen parameters like concentration, motility, and morphology, whereas an animal protein-rich diet exhibited the opposite effect.<a href=\"#fn138\" class=\"footnote-ref\" id=\"fnref138\" role=\"doc-noteref\"><sup>138<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Multi-antioxidant supplementation is an emerging therapy for male infertility due to the synergistic effect of multi-antioxidants. A study on 32 infertile men with idiopathic oligoasthenozoospermia, demonstrated a notable increase in sperm concentration, progressive motility, and total motility when treated with a multi-antioxidant oral supplement caplet for 3 months. The capsule consisted of vitamin C (90 mg\/day), vitamin E (15 mg\/day), selenium (30 \u00b5g\/day), coenzyme Q10 (4 mg\/day), and zinc (5 mg\/day).<a href=\"#fn139\" class=\"footnote-ref\" id=\"fnref139\" role=\"doc-noteref\"><sup>139<\/sup><\/a> Comparably, the administration of multi-antioxidant supplements (consisting of 50 mg coenzyme-Q10, 500 mg L-carnitine: 2.5 mg lycopene, and 12.5 mg zinc) for 3 months leads to a significant improvement in sperm count and total motility in 138 men with oligoastheonoteratozoospermia.<a href=\"#fn140\" class=\"footnote-ref\" id=\"fnref140\" role=\"doc-noteref\"><sup>140<\/sup><\/a> Despite some positive findings, the evidence supporting the effectiveness of antioxidants in treating male infertility is not conclusive. Further research is needed to establish standardized guidelines for multi-antioxidant use in male infertility treatment. Large, well-designed randomized controlled trials are necessary to determine the optimal combinations and dosages of antioxidants and to assess their long-term safety and\u00a0efficacy.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"who-are-the-experts\">Who are the Experts<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Several renowned researchers and experts in the field of male infertility have made significant contributions to understanding its causes and treatments. Some notable names include:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Peter Schlegel \u2013 A leading expert in male infertility and microsurgery. Dr. Schlegel is an internationally recognized urologist. He has served as Chair of Urology at Weill Cornell Medicine and has authored numerous papers on male infertility and sperm retrieval techniques. Dr. Schlegel\u2019s contributions to the field of male infertility are extensive. He has developed new genetic analyses to understand the causes of the severe form of male infertility known as non-obstructive azoospermia. His research has identified nearly 25 additional genetic causes of infertility that can lead to new treatments. He was the first to publish articles on the medical treatment of infertility with aromatase inhibitors and demonstrate the value of such treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Abstract of relevant published work:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.auajournals.org\/doi\/abs\/10.1097\/JU.0000000000001521\"><u>Diagnosis and treatment of infertility in men: AUA\/ASRM guideline part I<\/u><\/a> (American Urological Association Journal, January 1, 2021)<a href=\"#fn141\" class=\"footnote-ref\" id=\"fnref141\" role=\"doc-noteref\"><sup>141<\/sup><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.fertstert.org\/article\/S0015-0282(02)03105-9\/abstract\"><u>Best practice policies for male infertility<\/u><\/a><a href=\"#fn142\" class=\"footnote-ref\" id=\"fnref142\" role=\"doc-noteref\"><sup>142<\/sup><\/a> (Elsevier, May 6, 2002)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.auajournals.org\/doi\/abs\/10.1097\/JU.0000000000001520\"><u>Diagnosis and treatment of infertility in men: AUA\/ASRM guideline part II<\/u><\/a><a href=\"#fn143\" class=\"footnote-ref\" id=\"fnref143\" role=\"doc-noteref\"><sup>143<\/sup><\/a> (American Urological Association Journal, January 1, 2021)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0015028212023357\"><u>Aromatase inhibitors for male infertility<\/u><\/a><a href=\"#fn144\" class=\"footnote-ref\" id=\"fnref144\" role=\"doc-noteref\"><sup>144<\/sup><\/a> (Elsevier, October 25, 2012)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Prof. Allan Pacey \u2013 Prof. Pacey is a professor of andrology who serves as deputy vice president and deputy dean of the faculty of biology, medicine, and health at the University of Manchester, United Kingdom. Prof. Pacey is known for his research on male infertility, particularly in sperm quality and the genetic factors influencing infertility. He has been awarded Honorary Membership of the British Fertility Society (BFS) for his exceptional contributions to research, scholarship, and public engagement in male infertility over the past 30 years.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Abstract of relevant published work:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14647273.2019.1611281\"><u>Male fertility\u00a0and the need for more research<\/u><\/a><a href=\"#fn145\" class=\"footnote-ref\" id=\"fnref145\" role=\"doc-noteref\"><sup>145<\/sup><\/a> (Taylor &amp; Francis, May 6, 2019)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B978012372568400015X\"><u>Sperm, human fertility and society<\/u><\/a><a href=\"#fn146\" class=\"footnote-ref\" id=\"fnref146\" role=\"doc-noteref\"><sup>146<\/sup><\/a> (Elsevier, September 8, 2009)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Ashok Agarwal \u2013 A pioneer in the field of male infertility, Dr. Agarwal is a recognized expert and Director of the Andrology Center at the Cleveland Clinic, Ohio, US. His research has focused on sperm dysfunction, oxidative stress, and advanced laboratory techniques in male infertility. Ashok is ranked in Scopus as the top-ranking author worldwide in the fields of Male Infertility\/Andrology and Human Assisted Reproduction, based on his number of peer-reviewed publications, citation scores, and Hirsch index (h-index).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Abstract of relevant published work:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><u>\u00a0<a href=\"https:\/\/www.mdpi.com\/2076-3921\/8\/10\/488\">Effect of antioxidant supplementation on the sperm proteome of idiopathic infertile\u00a0men<\/a><\/u><a href=\"#fn147\" class=\"footnote-ref\" id=\"fnref147\" role=\"doc-noteref\"><sup>147<\/sup><\/a> <u>(MDPI, October 16, 2019)<\/u><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.3109\/14647273.2010.532279\"><u>The role of antioxidant therapy in the treatment of\u00a0male infertility<\/u><\/a><a href=\"#fn148\" class=\"footnote-ref\" id=\"fnref148\" role=\"doc-noteref\"><sup>148<\/sup><\/a> (Taylor &amp; Francis, November 30, 2010)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/and.13617\"><u>Obesity and\u00a0male infertility: Mechanisms and management<\/u><\/a><a href=\"#fn149\" class=\"footnote-ref\" id=\"fnref149\" role=\"doc-noteref\"><sup>149<\/sup><\/a> <u>(Wiley, May 12, 2020)<\/u><\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"positions-and-views-of-worldwide-governmental-medical-and-health-organizations\">Positions and Views of Worldwide Governmental Medical and Health Organizations<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">The positions and views of governmental medical and health organizations on male infertility vary by country but generally emphasize its importance as a public health issue. These organizations are concerned with male infertility for several reasons: its impact on family planning, its association with underlying health problems, and the psychological and emotional burden it can place on individuals and couples. Here is a summary of some global perspectives on male infertility:<\/p>\n\n\n\n<ul>\n<li><p>Positions from the Medical Community<\/p>\n<ul>\n<li><p>Agency for Healthcare Research and Quality (<a href=\"https:\/\/www.ahrq.gov\/\"><u>AHRQ<\/u><\/a>)<\/p>\n<ul>\n<li><p> <u><a href=\"https:\/\/effectivehealthcare.ahrq.gov\/health-topics\/male-infertility\/?_gl=1*rk8e8o*_ga*MTQzOTc4MzIzNS4xNzMzNTMwNzk2*_ga_45NDTD15CJ*MTczMzUzMDgxMS4xLjEuMTczMzUzMDgyMi40OS4wLjA.\">Male\u00a0Infertility\u00a0| Effective Health Care (EHC) Program<\/a> (AHRQ 2024)<\/u><a href=\"#fn150\" class=\"footnote-ref\" id=\"fnref150\" role=\"doc-noteref\"><sup>150<\/sup><\/a><\/p><\/li>\n<\/ul><\/li>\n<li><p>National Institute for Health and Care Excellence (<a href=\"https:\/\/www.nice.org.uk\/\"><u>NICE), United K<\/u><\/a>ingdom<\/p>\n<ul>\n<li><p><u>Fertility problems: assessment and treatment (NICE 2013)<\/u><a href=\"#fn151\" class=\"footnote-ref\" id=\"fnref151\" role=\"doc-noteref\"><sup>151<\/sup><\/a><\/p><\/li>\n<\/ul><\/li>\n<\/ul><\/li>\n<li><p>Worldwide Governmental Websites on Male Infertility<\/p>\n<ul>\n<li><p>WHO on male infertility and semen analysis.<\/p>\n<ul>\n<li><p><a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/infertility\"><u>Infertility (WHO 2014)<\/u><\/a><a href=\"#fn152\" class=\"footnote-ref\" id=\"fnref152\" role=\"doc-noteref\"><sup>152<\/sup><\/a><\/p><\/li>\n<li><p>\u00a0<a href=\"https:\/\/www.who.int\/publications-detail-redirect\/9789240030787\"><u>WHO laboratory manual for the examination and processing of human semen<\/u><\/a> for investigating male fertility status (WHO 2024)<a href=\"#fn153\" class=\"footnote-ref\" id=\"fnref153\" role=\"doc-noteref\"><sup>153<\/sup><\/a><\/p><\/li>\n<\/ul><\/li>\n<li><p>NIH (USA) on male infertility and its diagnosis and treatment.<\/p>\n<ul>\n<li><p><u><a href=\"https:\/\/www.auajournals.org\/doi\/abs\/10.1097\/JU.0000000000001520\">Diagnosis and treatment of infertility in men: AUA\/ASRM guideline part II<\/a> (NIH 2021)<\/u><\/p><\/li>\n<li><p>Updates to Male Infertility: AUA\/ASRM Guideline (2024) (NIH 2024)<a href=\"#fn154\" class=\"footnote-ref\" id=\"fnref154\" role=\"doc-noteref\"><sup>154<\/sup><\/a><\/p><\/li>\n<\/ul><\/li>\n<li><p>NHS (UK) on male infertility and its causes<\/p>\n<ul>\n<li><p><u>Low sperm count (NHS 2017)<\/u><a href=\"#fn155\" class=\"footnote-ref\" id=\"fnref155\" role=\"doc-noteref\"><sup>155<\/sup><\/a><\/p><\/li>\n<li><p><u>Causes of infertility (NHS 2017)<\/u><a href=\"#fn156\" class=\"footnote-ref\" id=\"fnref156\" role=\"doc-noteref\"><sup>156<\/sup><\/a><\/p><\/li>\n<\/ul><\/li>\n<li><p>CDC.gov (USA) on male infertility, its causes, and treatment<\/p>\n<ul>\n<li><p><u>Infertility: Frequently Asked Questions | Reproductive Health (CDC 2024)<\/u><a href=\"#fn157\" class=\"footnote-ref\" id=\"fnref157\" role=\"doc-noteref\"><sup>157<\/sup><\/a><\/p><\/li>\n<\/ul><\/li>\n<li><p><a href=\"https:\/\/www.canada.ca\/en\/public-health.html\">Public Health Agency of Canada<\/a> on male infertility and assisted human reproduction.<\/p>\n<ul>\n<li><p><a href=\"https:\/\/www.canada.ca\/en\/health-canada\/services\/drugs-health-products\/biologics-radiopharmaceuticals-genetic-therapies\/legislation-guidelines\/assisted-human-reproduction.html\"><u>Assisted human reproduction (<\/u><\/a><a href=\"https:\/\/www.canada.ca\/en\/public-health.html\">Public Health Agency of Canada<\/a> <a href=\"https:\/\/www.canada.ca\/en\/health-canada\/services\/drugs-health-products\/biologics-radiopharmaceuticals-genetic-therapies\/legislation-guidelines\/assisted-human-reproduction.html\">2024)<\/a><a href=\"#fn158\" class=\"footnote-ref\" id=\"fnref158\" role=\"doc-noteref\"><sup>158<\/sup><\/a><\/p><\/li>\n<\/ul><\/li>\n<li><p>Department of Health (Ireland)<\/p>\n<ul>\n<li><p><a href=\"https:\/\/www.gov.ie\/en\/press-release\/2d19d3-minister-for-health-announces-plans-to-roll-out-a-model-of-care-for-\/\"><u>Minister for Health announces plans to roll out a Model of Care for Infertility<\/u><\/a> (Department of Health 2019)<a href=\"#fn159\" class=\"footnote-ref\" id=\"fnref159\" role=\"doc-noteref\"><sup>159<\/sup><\/a><\/p><\/li>\n<\/ul><\/li>\n<\/ul><\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"nonprofits-and-private-organizations\">Nonprofits and Private Organizations<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">There are many nonprofit and private organizations focused on male infertility, offering resources, support, and advocacy. These organizations work to raise awareness about male infertility, provide educational materials, and help individuals access treatment options. Below is a list of some of these organizations:<\/p>\n\n\n\n<ul>\n<li><p>Nonprofit and Private Organizations:<\/p>\n<ul>\n<li><p>American Society for Reproductive Medicine (ASRM)<\/p>\n<ul>\n<li><p>Purpose\/Mission statement: \u201cASRM&#8217;s mission is to lead the advancement of reproductive medicine through evidence-based ethical practice, education, research, and advocacy\u201d. ASRM is a professional organization that includes resources about male infertility, its causes, diagnosis, and treatment options. It provides educational materials and offers support for healthcare providers and patients alike. It provides a platform for male infertility specialists\u00a0and patients to access the latest science, journals, courses, opinion documents, and networking opportunities. ASRM mission page.<a href=\"#fn160\" class=\"footnote-ref\" id=\"fnref160\" role=\"doc-noteref\"><sup>160<\/sup><\/a><\/p><\/li>\n<\/ul><\/li>\n<\/ul><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Website: <u><a href=\"https:\/\/www.asrm.org\">asrm.org<\/a><\/u><\/p>\n\n\n\n<ul>\n<li><p>Social media accounts: Instagram: @asrm_org \/\/ LinkedIn: https:\/\/www.linkedin.com\/company\/american-society-for-reproductive-medicine\/ \/\/YouTube: <a href=\"http:\/\/www.youtube.com\/@ASRMEducation\">www.youtube.com\/@ASRMEducation<\/a> \/\/Facebook: <u>https:\/\/www.facebook.com\/ASRMFB\/ \/\/Twitter: @ASRM_org<\/u><\/p><\/li>\n<\/ul>\n\n\n\n<ul>\n<li><p>National Infertility Association (RESOLVE)<\/p>\n<ul>\n<li><p>Purpose\/Mission statement: \u201cRESOLVE is a nonprofit organization dedicated to ensuring that all people challenged in their family-building journey reach a resolution through being empowered by knowledge, supported by the community, united by advocacy, and inspired to act\u201d. They provide support for individuals and couples facing infertility, including male infertility. They offer educational materials, resources for finding support groups, and advocacy efforts to improve access to fertility care. National Infertility Association (RESOLVE) mission page.<a href=\"#fn161\" class=\"footnote-ref\" id=\"fnref161\" role=\"doc-noteref\"><sup>161<\/sup><\/a><\/p><\/li>\n<\/ul><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Website: <a href=\"https:\/\/resolve.org\"><u>resolve.org<\/u><\/a><\/p>\n\n\n\n<ul>\n<li><p>Social media accounts: Instagram: @<u>resolveorg \/\/ Twitter: @resolveorg \/\/ Facebook: https:\/\/www.facebook.com\/resolveinfertilityorg\/ \/\/ Linkedln: https:\/\/www.linkedin.com\/company\/resolve-the-national-infertility-association\/ \/\/YouTube: https:\/\/www.youtube.com\/c\/ResolveOrg<\/u><\/p><\/li>\n<\/ul>\n\n\n\n<ul>\n<li><p>FertilityIQ<\/p>\n<ul>\n<li><p>Purpose\/Mission statement: \u201cFertilityIQ\u2019s goal is to deliver critical education to people when they need it most &#8211; so they can navigate life\u2019s most complex inflection points\u201d.<a href=\"#fn162\" class=\"footnote-ref\" id=\"fnref162\" role=\"doc-noteref\"><sup>162<\/sup><\/a> They offer ratings and reviews of fertility clinics, including those that treat male infertility. It provides a platform for men to research various treatments, clinics, and procedures related to infertility.<\/p><\/li>\n<\/ul><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Website: <u><a href=\"https:\/\/www.fertilityiq.com\">fertilityiq.com<\/a><\/u><\/p>\n\n\n\n<ul>\n<li><p>Social media accounts: Instagram: @fertilityiq \/\/Twitter: @FertilityIQ \/\/Facebook: https:\/\/www.facebook.com\/FertilityIQ\/<\/p><\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"social-media-contributors\">Social Media Contributors<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Platforms that frequently discuss the topic of male fertility, health, and wellness are:<\/p>\n\n\n\n<ul>\n<li><p>Michigan Medicine<\/p>\n<ul>\n<li><p>Michigan Medicine\u00a0is a premier, highly ranked academic medical center and award-winning healthcare system of the University of Michigan<strong>.<\/strong> Their social media accounts provide podcasts addressing male infertility, among other fertility topics. It often includes insights from doctors and individuals who have experienced infertility, offering support and education on both male and female fertility issues.<\/p><\/li>\n<\/ul><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Website:<a href=\"https:\/\/www.youtube.com\/redirect?event=channel_header&amp;redir_token=QUFFLUhqbkRSWk42Q2JsY1ZjYTZPLThwTHZUWG1JTlpDQXxBQ3Jtc0trTjJBektxd1gyQTMxT3VWRG5MaFNaNUxPNkdzWG5yR0RicW5GYXZJZWVhSzVpOXFObmJmYjFJTkcyMlNlaDhjOVVFYVQ2N3FGN1NEdm1VakZfRWtkemQ4U1ExbHByRVVxQ25VWXVUWU8xcXVXY0FPaw&amp;q=http%3A%2F%2FUofMHealth.org\"><u>uofmhealth.org<\/u><\/a><\/p>\n\n\n\n<ul>\n<li><p>Social media accounts: Instagram (30K+ followers): @umichmedicine\/\/ LinkedIn (92K+ Followers): <a href=\"https:\/\/www.linkedin.com\/company\/michigan-medicine\/%20\/\/%20Youtube\"><u>https:\/\/www.linkedin.com\/company\/michigan-medicine\/ \/\/ Youtube<\/u><\/a> (200K+ Subscribers):<a href=\"http:\/\/www.youtube.com\/@MichiganMedicine\">www.youtube.com\/@MichiganMedicine<\/a> \/\/Facebook (89.2K+ Followers): <a href=\"http:\/\/on.fb.me\/michiganmedicine%20\/\/\"><u>http:\/\/on.fb.me\/michiganmedicine \/\/<\/u><\/a> Twitter (43K+ Followers):@umichmedicine<\/p><\/li>\n<\/ul>\n\n\n\n<ul>\n<li><p>Fertile Minds<\/p>\n<ul>\n<li><p>The Fertile Minds platform provides the latest research, studies, and information to help you understand fertility. It is brought to you by IVF Australia, Melbourne IVF, Queensland Fertility Group, and TasIVF.<\/p><\/li>\n<li><p>Social media accounts: YouTube (33.3K+ Subscribers): <a href=\"http:\/\/www.youtube.com\/@FertileMinds\"><u>www.youtube.com\/@FertileMinds<\/u><\/a> \/\/ TikTok (137 Followers):<u>tiktok.com\/@fertileminds?is_from_webapp=1&amp;sender_device=pc<\/u><\/p><\/li>\n<\/ul><\/li>\n<li><p>NutritionFacts.org<\/p>\n<ul>\n<li><p>It is a science-based nonprofit organization founded by Michael Greger, M.D. Fellow of the American College of Lifestyle Medicine (FACLM), provides free updates on the latest research on male infertility and its link to nutrition via bite-sized videos, blogs, podcasts, and infographics.<\/p><\/li>\n<\/ul><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Website: <u>nutritionfacts.org<\/u><\/p>\n\n\n\n<ul>\n<li><p>Social media accounts: Instagram (1.2M+ followers):<a href=\"http:\/\/www.youtube.com\/@NutritionFactsOrg\"><u>www.youtube.com\/@NutritionFactsOrg<\/u><\/a> \/\/YouTube (1.21M+ Subscribers):<a href=\"http:\/\/www.youtube.com\/@NutritionFactsOrg\"><u>www.youtube.com\/@NutritionFactsOrg<\/u><\/a> \/\/Facebook (881K+ Followers): <a href=\"http:\/\/on.fb.me\/michiganmedicine%20%20\/\/\"><u>facebook.com\/NutritionFacts.org\/\/<\/u><\/a> Twitter (153.5K+ Followers):<a href=\"https:\/\/www.youtube.com\/redirect?event=channel_description&amp;redir_token=QUFFLUhqbUl3VHV2X0VoeFRNWUFhM2FPRGYzbzNyczZWd3xBQ3Jtc0tuQmVEWWVmQ29XRDVodG1NbDJHMVBmNm5XX2VXa0NxLV9qNGRLV3hXdVdVYVhnVUIzWVhpZ1FFRGFQeFdpRGIydThCaTlKWWUtaTJtVkFEajFESm9JV0tWRjBZY1NqSmJxaEpFMTVQdEVCVk8zdjJ0RQ&amp;q=http%3A%2F%2Ftwitter.com%2Fnutrition_facts\"><u>twitter.com\/nutrition_fact<\/u><\/a><\/p><\/li>\n<\/ul>\n\n\n\n<ul>\n<li><p>Maze Men\u2019s Sexual &amp; Reproductive Health<\/p>\n<ul>\n<li><p>A channel of Dr. Michael A. Werner, MD, who is a board-certified, fellowship-trained urologist. His practice is limited to sexual dysfunction and male infertility.<\/p><\/li>\n<\/ul><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Website: <u>mazehealth.com<\/u><\/p>\n\n\n\n<ul>\n<li><p>Social media accounts: Instagram (20.3k+ followers)\/\/YouTube (7.12k+ Subscribers): <u>www.youtube.com\/@mazewerner\/videos<\/u> \/\/Facebook (7.9K+ Followers): <a href=\"http:\/\/on.fb.me\/michiganmedicine%20%20\/\/\"><u>facebook.com\/MazeMensHealth\/\/<\/u><\/a> Twitter (1.1K+ Followers): <a href=\"https:\/\/www.youtube.com\/redirect?event=channel_description&amp;redir_token=QUFFLUhqbkw4Skw3STlaYndTNG5qdGZJbEc1OFNwc01DQXxBQ3Jtc0trUExEcnlfY2pZeTFDcG0tR3NVaDhaNldaMVpmZWUzUl8tbmViRzRuV25FUHFfWndiUFBaTjBZS1JkSDV2ZURlVXBrSm9Ienc4NjhYdEFmSHpNVDczZ3pyX3NyMXJtSXJWa25EU1kwQkFXV2tPT2ozVQ&amp;q=https%3A%2F%2Ftwitter.com%2Fmazemenshealth\"><u>twitter.com\/mazemenshealth<\/u><\/a><\/p><\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"bibliography\">Bibliography<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Abdollahi, Nooshin, Mehran Nouri, Kimia Leilami, Yasser Fakri Mustafa, and Mahsa Shirani. \u201cThe Relationship between Plant and Animal Based Protein with Semen Parameters: A Cross-Sectional Study in Infertile Men.\u201d <em>Clinical Nutrition ESPEN<\/em> 49 (June 2022): 372\u201377. https:\/\/doi.org\/10.1016\/j.clnesp.2022.03.019.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Adekunbi, D.A., O.A. Ogunsola, O.T. Oyelowo, E.O. Aluko, A.A. Popoola, and O.O. Akinboboye. \u201cConsumption of High Sucrose and\/or High Salt Diet Alters Sperm Function in Male Sprague\u2013Dawley Rats.\u201d <em>Egyptian Journal of Basic and Applied Sciences<\/em> 3, no. 2 (June 2016): 194\u2013201. https:\/\/doi.org\/10.1016\/j.ejbas.2016.03.003.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Agarwal, Ashok, Aditi A. Mulgund, Alaa J. Hamada, and Michelle Renee Chyatte. \u201cA Unique View on Male Infertility around the Globe.\u201d <em>Reproductive Biology and Endocrinology\u202f: RB&amp;E<\/em> 13 (2015). https:\/\/doi.org\/10.1186\/s12958-015-0032-1.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Agarwal, Ashok, Manesh Kumar Panner Selvam, Luna Samanta, Sarah C. Vij, Neel Parekh, Edmund Sabanegh, Nicholas N. Tadros, Mohamed Arafa, and Rakesh Sharma. \u201cEffect of Antioxidant Supplementation on the Sperm Proteome of Idiopathic Infertile Men.\u201d <em>Antioxidants<\/em> 8, no. 10 (October 16, 2019): 488. https:\/\/doi.org\/10.3390\/antiox8100488.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Agarwal, Ashok, and Lucky H. Sekhon. \u201cThe Role of Antioxidant Therapy in the Treatment of Male Infertility.\u201d <em>Human Fertility<\/em> 13, no. 4 (December 2010): 217\u201325. https:\/\/doi.org\/10.3109\/14647273.2010.532279.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ahmadi, Sedigheh, Reihane Bashiri, Akram Ghadiri-Anari, and Azadeh Nadjarzadeh. \u201cAntioxidant Supplements and Semen Parameters: An Evidence Based Review.\u201d <em>International Journal of Reproductive Biomedicine<\/em> 14, no. 12 (December 2016): 729\u201336.https:\/\/doi.org\/10.29252\/ijrm.14.12.729.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ajuogu, Peter Kelechi, Mohammed Ak Al-Aqbi, Robert A Hart, Mitchell Wolden, Neil A Smart, and James R McFarlane. \u201cThe Effect of Dietary Protein Intake on Factors Associated with Male Infertility: A Systematic Literature Review and Meta-Analysis of Animal Clinical Trials in Rats.\u201d <em>Nutrition and Health<\/em> 26, no. 1 (March 2020): 53\u201364. https:\/\/doi.org\/10.1177\/0260106019900731.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Akmal, Mohammed, J.Q. Qadri, Noori S. Al-Waili, Shahiya Thangal, Afrozul Haq, and Khelod Y. Saloom. \u201cImprovement in Human Semen Quality After Oral Supplementation of Vitamin C.\u201d <em>Journal of Medicinal Food<\/em> 9, no. 3 (September 2006): 440\u201342. https:\/\/doi.org\/10.1089\/jmf.2006.9.440.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Al Tarique, Mostafa M., Jesmine Banu, Nastaran Lasker, S. M. Munira, Shahin Ara Anwary, Tandra Ghosh, Sharmin Sultana, Rawnok Laila, Asma Akter, and Makshoda Begum. \u201cEffects of Levo-Carnitine in Infertile Men with Asthenozoospermia: A Randomized Placebo-Controlled Trial.\u201d <em>International Journal of Reproduction, Contraception, Obstetrics and Gynecology<\/em> 13, no. 6 (May 29, 2024): 1409\u201314. https:\/\/doi.org\/10.18203\/2320-1770.ijrcog20241421.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Alahmar, Ahmed T. \u201cEffect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia.\u201d <em>International Journal of Infertility &amp; Fetal Medicine<\/em> 8, no. 2 (August 2017): 45\u201349. https:\/\/doi.org\/10.5005\/jp-journals-10016-1147.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Alahmar, Ahmed T. \u201cThe Impact of Two Doses of Coenzyme Q10 on Semen Parameters and Antioxidant Status in Men with Idiopathic Oligoasthenoteratozoospermia.\u201d <em>Clinical and Experimental Reproductive Medicine<\/em> 46, no. 3 (September 2019): 112\u201318. https:\/\/doi.org\/10.5653\/cerm.2019.00136.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ambiye, Vijay R., Deepak Langade, Swati Dongre, Pradnya Aptikar, Madhura Kulkarni, and Atul Dongre. \u201cClinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha ( <em>Withania Somnifera<\/em> ) in Oligospermic Males: A Pilot Study.\u201d <em>Evidence-Based Complementary and Alternative Medicine<\/em> 2013 (2013): 1\u20136. https:\/\/doi.org\/10.1155\/2013\/571420.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cClinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha ( <em>Withania Somnifera<\/em> ) in Oligospermic Males: A Pilot Study.\u201d <em>Evidence-Based Complementary and Alternative Medicine<\/em> 2013 (2013): 1\u20136. https:\/\/doi.org\/10.1155\/2013\/571420.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Amor, Houda, Yaser Alkhaled, Riffat Bibi, Mohamad Eid Hammadeh, and Peter Michael Jankowski. \u201cThe Impact of Heavy Smoking on Male Infertility and Its Correlation with the Expression Levels of the PTPRN2 and PGAM5 Genes.\u201d <em>Genes<\/em> 14, no. 8 (August 12, 2023): 1617. https:\/\/doi.org\/10.3390\/genes14081617.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Argent, Emmanuelle Mathieu d\u2019, C\u00e9lia Ravel, Alexandra Rousseau, Karine Morcel, Nathalie Massin, Julie Sussfeld, Tabassome Simon, et al. \u201cHigh-Dose Supplementation of Folic Acid in Infertile Men Improves IVF-ICSI Outcomes: A Randomized Controlled Trial (FOLFIV Trial).\u201d <em>Journal of Clinical Medicine<\/em> 10 (2021). <a href=\"https:\/\/doi.org\/10.3390\/jcm10091876\"><u>\u00a0https:\/\/doi.org\/10.3390\/jcm10091876\u00a0<\/u><\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bendera, Richard, and Leanna S. Wilson. \u201cThe Regulatory Effect of Biogenic Polyamines Spermine and Spermidine in Men and Women.\u201d <em>Open Journal of Endocrine and Metabolic Diseases<\/em> 09, no. 03 (2019): 35\u201348. https:\/\/doi.org\/10.4236\/ojemd.2019.93004.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Biggs, Sarah, Jane Halliday, and Karin Hammarberg. \u201cPsychological Consequences of a Diagnosis of Infertility in Men: A Systematic Analysis.\u201d <em>Asian Journal of Andrology<\/em> 26 (2023): 10\u201319. https:\/\/doi.org\/10.4103\/aja202334.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Boonyarangkul, Arthit, Nipattha Vinayanuvattikhun, Charoenchai Chiamchanya, and Pachara Visutakul. \u201cComparative Study of the Effects of Tamoxifen Citrate and Folate on Semen Quality of the Infertile Male with Semen Abnormality.\u201d <em>Journal of the Medical Association of Thailand Chotmaihet Thangphaet<\/em> 98, no. 11 (November 2015): 1057\u201363.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Braesco, V\u00e9ronique, Isabelle Souchon, Patrick Sauvant, Typhaine Haurogn\u00e9, Matthieu Maillot, Catherine F\u00e9art, and Nicole Darmon. \u201cUltra-Processed Foods: How Functional Is the NOVA System?\u201d <em>European Journal of Clinical Nutrition<\/em> 76, no. 9 (September 2022): 1245\u201353. https:\/\/doi.org\/10.1038\/s41430-022-01099-1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Brannigan, Robert E., Linnea Hermanson, Janice Kaczmarek, Sennett K. Kim, Erin Kirkby, and Cigdem Tanrikut. \u201cUpdates to Male Infertility: AUA\/ASRM Guideline (2024).\u201d <em>Journal of Urology<\/em> 212, no. 6 (December 2024): 789\u201399. https:\/\/doi.org\/10.1097\/JU.0000000000004180.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Brighten, Dr Jolene. \u201c25 Health Benefits of Omega-3 Fatty Acids.\u201d Dr. Jolene Brighten, March 7, 2020. https:\/\/drbrighten.com\/25-health-benefits-of-omega-3-fatty-acids\/.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Burch, James B, Sara Wagner Robb, Robin Puett, Bo Cai, Rebecca Wilkerson, Wilfried Karmaus, John Vena, and Erik Svendsen. \u201cMercury in Fish and Adverse Reproductive Outcomes: Results from South Carolina.\u201d <em>International Journal of Health Geographics<\/em> 13, no. 1 (2014): 30. https:\/\/doi.org\/10.1186\/1476-072X-13-30.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Canada, Health. \u201cAssisted Human Reproduction.\u201d Decisions, July 26, 2004. https:\/\/www.canada.ca\/en\/health-canada\/services\/drugs-health-products\/biologics-radiopharmaceuticals-genetic-therapies\/legislation-guidelines\/assisted-human-reproduction.html.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CDC. \u201cInfertility: Frequently Asked Questions.\u201d Reproductive Health, November 25, 2024. https:\/\/www.cdc.gov\/reproductive-health\/infertility-faq\/index.html.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Chavarro, Jorge E., Thomas L. Toth, Sonita M. Sadio, and Russ Hauser. \u201cSoy Food and Isoflavone Intake in Relation to Semen Quality Parameters among Men from an Infertility Clinic.\u201d <em>Human Reproduction (Oxford, England)<\/em> 23, no. 11 (November 2008): 2584\u201390. https:\/\/doi.org\/10.1093\/humrep\/den243.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Chereshnev, Valeriy A., Svetlana V. Pichugova, Yakov B. Beikin, Margarita V. Chereshneva, Angelina I. Iukhta, Yuri I. Stroev, and Leonid P. Churilov. \u201cPathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation.\u201d <em>Pathophysiology: The Official Journal of the International Society for Pathophysiology<\/em> 28, no. 4 (October 15, 2021): 471\u201388. https:\/\/doi.org\/10.3390\/pathophysiology28040030.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Chiu, Y.H., M.C. Afeiche, A.J. Gaskins, P.L. Williams, J.C. Petrozza, C. Tanrikut, R. Hauser, and J.E. Chavarro. \u201cFruit and Vegetable Intake and Their Pesticide Residues in Relation to Semen Quality among Men from a Fertility Clinic.\u201d <em>Human Reproduction<\/em> 30, no. 6 (June 2015): 1342\u201351. https:\/\/doi.org\/10.1093\/humrep\/dev064.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Choy, Christine M.Y., Queenie S.Y. Yeung, Christine M. Briton-Jones, Chi-Kwok Cheung, Christopher W.K. Lam, and Christopher J. Haines. \u201cRelationship between Semen Parameters and Mercury Concentrations in Blood and in Seminal Fluid from Subfertile Males in Hong Kong.\u201d <em>Fertility and Sterility<\/em> 78, no. 2 (August 2002): 426\u201328. https:\/\/doi.org\/10.1016\/S0015-0282(02)03232-6.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cleveland Clinic. \u201cGinseng: Uses, Interactions &amp; Side Effects.\u201d Accessed November 24, 2024. https:\/\/my.clevelandclinic.org\/health\/drugs\/19105-ginseng-capsules-or-tablets.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CNET. \u201c15 Best Food Sources of Zinc.\u201d Accessed November 26, 2024. https:\/\/www.cnet.com\/health\/nutrition\/best-food-sources-of-zinc\/.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cyrus, Ali, Ali Kabir, Davood Goodarzi, and Mehrdad Moghimi. \u201cThe Effect of Adjuvant Vitamin C after Varicocele Surgery on Sperm Quality and Quantity in Infertile Men: A Double Blind Placebo Controlled Clinical Trial.\u201d <em>International Brazilian Journal of Urology\u202f: Official Journal of the Brazilian Society of Urology<\/em> 41 (2015): 230\u201338. https:\/\/doi.org\/10.1590\/s1677-5538.ibju.2015.02.07.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dabbous, Zeinab, and Stephen L. Atkin. \u201cHyperprolactinaemia in Male Infertility: Clinical Case Scenarios.\u201d <em>Arab Journal of Urology<\/em> 16, no. 1 (March 2018): 44\u201352. https:\/\/doi.org\/10.1016\/j.aju.2017.10.002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dai, Jing-Bo, Zhao-Xia Wang, and Zhong-Dong Qiao. \u201cThe Hazardous Effects of Tobacco Smoking on Male Fertility.\u201d <em>Asian Journal of Andrology<\/em> 17, no. 6 (2015): 954\u201360. https:\/\/doi.org\/10.4103\/1008-682X.150847.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Danielewicz, Anna, Katarzyna Przyby\u0142owicz, and Jakub Morze. \u201cProcessed Meat Intake in Relation to Semen Quality Indicators among Men Attending a Fertility Clinic.\u201d <em>Proceedings of the Nutrition Society<\/em> 79, no. OCE2 (2020): E650. https:\/\/doi.org\/10.1017\/S0029665120005996.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">D\u2019Aniello, Gemma, Salvatore Ronsini, Tiziana Notari, Natascia Grieco, Vincenzo Infante, Nicola D\u2019Angel, Fara Mascia, Maria Maddalena Di Fiore, George Fisher, and Antimo D\u2019Aniello. \u201cD-Aspartate, a Key Element for the Improvement of Sperm Quality.\u201d <em>Advances in Sexual Medicine<\/em> 02, no. 04 (2012): 45\u201353. https:\/\/doi.org\/10.4236\/asm.2012.24008.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Fallah, Ali, Azadeh Mohammad-Hasani, and Abasalt Hosseinzadeh Colagar. \u201cZinc Is an Essential Element for Male Fertility: A Review of Zn Roles in Men\u2019s Health, Germination, Sperm Quality, and Fertilization.\u201d <em>Journal of Reproduction &amp; Infertility<\/em> 19, no. 2 (2018): 69\u201381.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cFertilityIQ: All The Best Family Building Education.\u201d Accessed December 5, 2024. https:\/\/www.fertilityiq.com\/.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gaia Herbs. \u201cAshwagandha: 10 Side Effects &amp; Contraindications to Know.\u201d Accessed November 24, 2024. https:\/\/www.gaiaherbs.com\/blogs\/seeds-of-knowledge\/ashwagandha-side-effects.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gonzales, G. 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What the Research Says,\u201d September 21, 2023. https:\/\/www.healthline.com\/health\/does-ashwagandha-make-you-fertile.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Healthline. \u201cL-Carnitine &#8211; A Review of Benefits, Side Effects and Dosage,\u201d March 27, 2023. https:\/\/www.healthline.com\/nutrition\/l-carnitine.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Healthline. \u201cNormal Sperm Count: Understanding Your Semen Analysis,\u201d August 29, 2018. https:\/\/www.healthline.com\/health\/mens-health\/normal-sperm-count.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Healthline. \u201cShould You Avoid Fish Because of Mercury?,\u201d September 14, 2018. https:\/\/www.healthline.com\/nutrition\/mercury-content-of-fish.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThe Hormones That Drive Male Fertility | Legacy,\u201d February 4, 2023. https:\/\/www.givelegacy.com\/resources\/the-hormones-that-drive-male-fertility\/.https:\/\/www.givelegacy.com\/.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cVitamin D Rich Food- Fruits, Vegetables &amp; Other Sources.\u201d Accessed November 26, 2024. https:\/\/www.hdfcergo.com\/health-insurance\/wellness-corner\/vitamin-d-rich-food-in-india.https:\/\/www.hdfcergo.com\/.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">I. Abbas, Yasir, Mazin A. Yadigar, and Shayma S. Khuder. \u201cThe Effect of L-Carnitine Supplement on Seminal Fluid Parameters in Males with Infertility.\u201d <em>Tikrit Journal of Pharmaceutical Sciences<\/em> 13, no. 1 (April 26, 2023): 23\u201329. https:\/\/doi.org\/10.25130\/tjphs.2018.13.1.4.23.29.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cInfertility.\u201d Accessed December 6, 2024. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/infertility.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Jensen, T. K., S. H. Swan, N. E. Skakkebaek, S. Rasmussen, and N. 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Nugent and Anjani Chandra, \u201cInfertility and Impaired Fecundity in Women and Men in the United States, 2015-2019.,\u201d <em>National Health Statistics Reports<\/em> 202 (2024): 1\u201319. <a href=\"https:\/\/doi.org\/10.15620\/cdc\/147886\">https:\/\/doi.org\/10.15620\/cdc\/147886\u00a0<\/a>.<a href=\"#fnref2\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn3\"><p>Aris Kaltsas et al., \u201cEmpirical Treatments for Male Infertility: A Focus on Lifestyle Modifications and Medicines,\u201d <em>Diseases<\/em> 12, no. 9 (September 11, 2024): 209, https:\/\/doi.org\/10.3390\/diseases12090209.<a href=\"#fnref3\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn4\"><p>Stephen W. Leslie, Taylor L. 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Chiu et al., \u201cFruit and Vegetable Intake and Their Pesticide Residues in Relation to Semen Quality among Men from a Fertility Clinic,\u201d <em>Human Reproduction<\/em> 30, no. 6 (June 2015): 1342\u201351, https:\/\/doi.org\/10.1093\/humrep\/dev064.<a href=\"#fnref135\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn136\"><p>Mahdieh Raeeszadeh, Nadia Khademi, and Abolfazl Akbari, \u201cThe Effects of Broccoli and Caraway Extracts on Serum Oxidative Markers, Testicular Structure and Function, and Sperm Quality before and after Sperm Cryopreservation,\u201d <em>Cryobiology<\/em> 99 (April 2021): 11\u201319, https:\/\/doi.org\/10.1016\/j.cryobiol.2021.02.003.<a href=\"#fnref136\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn137\"><p>Peter Kelechi Ajuogu et al., \u201cThe Effect of Dietary Protein Intake on Factors Associated with Male Infertility: A Systematic Literature Review and Meta-Analysis of Animal Clinical Trials in Rats,\u201d <em>Nutrition and Health<\/em> 26, no. 1 (March 2020): 53\u201364, https:\/\/doi.org\/10.1177\/0260106019900731.<a href=\"#fnref137\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn138\"><p>Nooshin Abdollahi et al., \u201cThe Relationship between Plant and Animal Based Protein with Semen Parameters: A Cross-Sectional Study in Infertile Men,\u201d <em>Clinical Nutrition ESPEN<\/em> 49 (June 2022): 372\u201377, https:\/\/doi.org\/10.1016\/j.clnesp.2022.03.019.<a href=\"#fnref138\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn139\"><p>Ahmed T Alahmar, \u201cEffect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia,\u201d <em>International Journal of Infertility &amp; Fetal Medicine<\/em> 8, no. 2 (August 2017): 45\u201349, https:\/\/doi.org\/10.5005\/jp-journals-10016-1147.<a href=\"#fnref139\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn140\"><p>Sonia Malik et al., \u201cFixed Dose Combination Therapy of Antioxidants in Treatment of Idiopathic Oligoasthenozoospermia: Results of a Randomized, Double-Blind, Placebo-Controlled Clinical Trial,\u201d <em>International Journal of Infertility &amp; Fetal Medicine<\/em> 4, no. 1 (April 2013): 6\u201313, https:\/\/doi.org\/10.5005\/jp-journals-10016-1053.<a href=\"#fnref140\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn141\"><p>Peter N. Schlegel et al., \u201cDiagnosis and Treatment of Infertility in Men: AUA\/ASRM Guideline Part I,\u201d <em>Journal of Urology<\/em> 205, no. 1 (January 2021): 36\u201343, https:\/\/doi.org\/10.1097\/JU.0000000000001521.<a href=\"#fnref141\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn142\"><p>Ira D Sharlip et al., \u201cBest Practice Policies for Male Infertility,\u201d <em>Fertility and Sterility<\/em> 77, no. 5 (May 2002): 873\u201382, https:\/\/doi.org\/10.1016\/S0015-0282(02)03105-9.<a href=\"#fnref142\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn143\"><p>Peter N. Schlegel et al., \u201cDiagnosis and Treatment of Infertility in Men: AUA\/ASRM Guideline PART II,\u201d <em>Journal of Urology<\/em> 205, no. 1 (January 2021): 44\u201351, https:\/\/doi.org\/10.1097\/JU.0000000000001520.<a href=\"#fnref143\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn144\"><p>Peter N. Schlegel, \u201cAromatase Inhibitors for Male Infertility,\u201d <em>Fertility and Sterility<\/em> 98, no. 6 (December 2012): 1359\u201362, https:\/\/doi.org\/10.1016\/j.fertnstert.2012.10.023.<a href=\"#fnref144\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn145\"><p>Allan Pacey, \u201cMale Fertility and the Need for More Research,\u201d <em>Human Fertility<\/em> 22, no. 2 (April 3, 2019): 77\u201377, https:\/\/doi.org\/10.1080\/14647273.2019.1611281.<a href=\"#fnref145\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn146\"><p>Allan A. Pacey, \u201cSperm, Human Fertility and Society,\u201d in <em>Sperm Biology<\/em> (Elsevier, 2009), 565\u201397, https:\/\/doi.org\/10.1016\/B978-0-12-372568-4.00015-X.<a href=\"#fnref146\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn147\"><p>Ashok Agarwal et al., \u201cEffect of Antioxidant Supplementation on the Sperm Proteome of Idiopathic Infertile Men,\u201d <em>Antioxidants<\/em> 8, no. 10 (October 16, 2019): 488, https:\/\/doi.org\/10.3390\/antiox8100488.<a href=\"#fnref147\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn148\"><p>Ashok Agarwal and Lucky H. Sekhon, \u201cThe Role of Antioxidant Therapy in the Treatment of Male Infertility,\u201d <em>Human Fertility<\/em> 13, no. 4 (December 2010): 217\u201325, https:\/\/doi.org\/10.3109\/14647273.2010.532279.<a href=\"#fnref148\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn149\"><p>Kristian Leisegang et al., \u201cObesity and Male Infertility: Mechanisms and Management,\u201d <em>Andrologia<\/em> 53, no. 1 (February 2021), https:\/\/doi.org\/10.1111\/and.13617.<a href=\"#fnref149\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn150\"><p>\u201cMale Infertility | Effective Health Care (EHC) Program,\u201d accessed December 6, 2024, https:\/\/effectivehealthcare.ahrq.gov\/health-topics\/male-infertility?_gl=1*rk8e8o*_ga*MTQzOTc4MzIzNS4xNzMzNTMwNzk2*_ga_45NDTD15CJ*MTczMzUzMDgxMS4xLjEuMTczMzUzMDgyMi40OS4wLjA.<a href=\"#fnref150\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn151\"><p>\u201cOverview | Fertility Problems: Assessment and Treatment | Guidance | NICE,\u201d February 20, 2013, https:\/\/www.nice.org.uk\/guidance\/cg156.<a href=\"#fnref151\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn152\"><p>\u201cInfertility,\u201d accessed December 6, 2024, https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/infertility.<a href=\"#fnref152\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn153\"><p>\u201cWHO Laboratory Manual for the Examination and Processing of Human Semen,\u201d accessed December 6, 2024, https:\/\/www.who.int\/publications\/i\/item\/9789240030787.<a href=\"#fnref153\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn154\"><p>Robert E. Brannigan et al., \u201cUpdates to Male Infertility: AUA\/ASRM Guideline (2024),\u201d <em>Journal of Urology<\/em> 212, no. 6 (December 2024): 789\u201399, https:\/\/doi.org\/10.1097\/JU.0000000000004180.<a href=\"#fnref154\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn155\"><p>\u201cLow Sperm Count,\u201d nhs.uk, October 19, 2017, https:\/\/www.nhs.uk\/conditions\/low-sperm-count\/.<a href=\"#fnref155\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn156\"><p>\u201cCauses of Infertility,\u201d nhs.uk, October 23, 2017, https:\/\/www.nhs.uk\/conditions\/infertility\/causes\/.<a href=\"#fnref156\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn157\"><p>CDC, \u201cInfertility: Frequently Asked Questions,\u201d Reproductive Health, November 25, 2024, https:\/\/www.cdc.gov\/reproductive-health\/infertility-faq\/index.html.<a href=\"#fnref157\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn158\"><p>Health Canada, \u201cAssisted Human Reproduction,\u201d decisions, July 26, 2004, https:\/\/www.canada.ca\/en\/health-canada\/services\/drugs-health-products\/biologics-radiopharmaceuticals-genetic-therapies\/legislation-guidelines\/assisted-human-reproduction.html.<a href=\"#fnref158\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn159\"><p>\u201cMinister for Health Announces Plans to Roll out a Model of Care for Infertility,\u201d December 19, 2019, https:\/\/www.gov.ie\/en\/press-release\/2d19d3-minister-for-health-announces-plans-to-roll-out-a-model-of-care-for-\/.<a href=\"#fnref159\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn160\"><p>\u201cMission, Vision and Values,\u201d accessed December 5, 2024, https:\/\/www.asrm.org\/about-us\/about-asrm\/mission-vision-and-values\/.<a href=\"#fnref160\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn161\"><p>\u201cOur Mission | RESOLVE: The National Infertility Association,\u201d August 27, 2021, https:\/\/resolve.org\/about-us\/mission\/.<a href=\"#fnref161\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<li id=\"fn162\"><p>\u201cFertilityIQ: All The Best Family Building Education,\u201d accessed December 5, 2024, https:\/\/www.fertilityiq.com\/.<a href=\"#fnref162\" class=\"footnote-back\" role=\"doc-backlink\">\u21a9\ufe0e<\/a><\/p><\/li>\n<\/ol>\n<\/section>\n\n\n","protected":false},"excerpt":{"rendered":"<p>Report Author: Simran Sharma Report Date: March 3, 2025 Table of Contents Introduction Significance of the Topic Potential Cause of Male Infertility Hormonal Imbalance Sperm Quality Issue Immune Disorder Oxidative&hellip;<\/p>","protected":false},"author":67,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[11839],"tags":[],"class_list":["post-32083","post","type-post","status-publish","format-standard","hentry","category-disease-wellness-and-healthspan-evidenced-based-food-as-medicine-research-and-resource-guides"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.9 (Yoast SEO v27.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Vitality: Male Infertility and Diet &#8212;<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/foodmedcenter.org\/es_do\/vitality-male-infertility-and-diet\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vitality: Male Infertility and Diet\" \/>\n<meta property=\"og:description\" content=\"Report Author: Simran Sharma Report Date: March 3, 2025 Table of Contents Introduction Significance of the Topic Potential Cause of Male Infertility Hormonal Imbalance Sperm Quality Issue Immune Disorder Oxidative&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/foodmedcenter.org\/es_do\/vitality-male-infertility-and-diet\/\" \/>\n<meta property=\"og:site_name\" content=\"Center For Food As Medicine &amp; 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