{"id":19709,"date":"2025-08-25T09:09:10","date_gmt":"2025-08-25T13:09:10","guid":{"rendered":"https:\/\/foodmedcenter.org\/?p=19709"},"modified":"2025-08-25T09:09:12","modified_gmt":"2025-08-25T13:09:12","slug":"study-spotlight-take-away-with-chef-dr-mike-enter-sandman-the-gut-microbiome-and-insomnia","status":"publish","type":"post","link":"https:\/\/foodmedcenter.org\/es_pr\/study-spotlight-take-away-with-chef-dr-mike-enter-sandman-the-gut-microbiome-and-insomnia\/","title":{"rendered":"Study Spotlight Take-Away With Chef Dr. Mike: Enter Sandman: The Gut Microbiome and Insomnia"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><em>\u201cHush little baby, don&#8217;t say a word<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>And never mind that noise you heard<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>It&#8217;s just the beasts under your bed<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>In your closet, in your head\u2026\u201d<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>\u2014 <\/em>Metallica, Enter Sandman<\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">And to Metallica\u2019s homage to The Sandman, we can add the wee beasties in our belly. Insomnia, sleep deprivation, and poor sleep quality are major risk factors for the development of many chronic diseases. These include conditions like obesity, metabolic syndrome, type II diabetes, autoimmune disease, cardiovascular disease, as well as mental health concerns such as depression.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Given the deep interconnections between the gut and brain through the gut-brain axis, a link between disorders of sleep and chronic disabilities and diseases should not be surprising. However, remarkably, in terms of emphasizing proper sleep as a powerful and cost-effective part of any healthcare solution, a simple fix such as this is often ignored. This is especially significant given that the evidence of insomnia in the general population is estimated at up to around 20%, or one in five people, with half of the cases being chronic in nature.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This week\u2019s study adds evidence of the bidirectional nature of the gut-brain axis and the negative impact of insomnia on gut health.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/gpsych.bmj.com\/content\/38\/4\/e101855\">The Study:<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The study sought to examine the interaction between the human gut microbiota and insomnia.<\/li>\n\n\n\n<li>The study employed Mendelian randomization (MR) analysis incorporating the use of genome-wide association studies (GWAS) datasets on insomnia (N=386,533), and gut microbiota data from both the MiBioGen alliance (N=18,340) and the Dutch Microbiome Project (N=8,208).<\/li>\n\n\n\n<li>Gut microbiota abnormalities are associated with an increased risk of chronic disability and diseases such as allergies, obesity, metabolic syndrome, type II diabetes, cardiovascular disease, and a host of autoimmune diseases.<\/li>\n\n\n\n<li>Gut microbiota abnormalities are associated with an increased risk of neuropsychiatric pathologies such as cognitive impairment, depression, Parkinson\u2019s disease, and Alzheimer\u2019s disease.<\/li>\n\n\n\n<li>The researchers found 14 gut bacterial taxa that may increase the risk of insomnia and 8 gut bacterial taxa that reduce the risk of insomnia.<\/li>\n\n\n\n<li>The researchers also found that insomnia may cause an increase in the populations of 12 gut bacterial taxa and a decrease in the populations of 7 gut bacterial taxa.<\/li>\n\n\n\n<li>Specifically, the bacterial genus <em>Odoribacter<\/em>, was implicated as a potential causative force in the risk of developing insomnia.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><em>The Caveat:<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Changes to the human gut microbiome associated with sleep disturbances, including insomnia, are well documented. Patients suffering from insomnia exhibit changes in the quality and character of their gut microbiota, which includes not only bacteria but also viruses and fungi.<a href=\"#_ftn1\" id=\"_ftnref1\">[1]<\/a> Such changes are also associated with evidence of increased systemic inflammation, as evidenced by increased levels of interleukin-6 (IL-6) in patients with primary insomnia.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Whilst the gut microbiome is dynamic, changing rapidly in response to stress and diet and more slowly over time with aging, a healthy gut microbiota generally includes the bacterial phyla of <em>Firmicutes, Bacteroidetes, Actinobacteria,<\/em> and <em>Proteobacteria<\/em>, with <em>Firmicutes <\/em>and <em>Bacteroidetes<\/em> appearing to be co-dominant. Sleep deprivation, as well as sleep duration restriction and fragmentation, are associated with changes in the character and quality of the human gut microbiome.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This study provides increasing evidence regarding the deep interdependencies between mental health, physical health, and the health of our gut microbiome. Additionally, it emphasizes the bidirectional, conversational nature of the ever-present information exchange occurring via the gut-brain axis. This axis involves many roots of communication, including endocrine, neuronal, and immune signaling pathways. Such pathways, both directly and indirectly, contribute to the regulation of neurological function, learning, memory, and emotion.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Although all too frequently overlooked by healthcare professionals and virtually ignored within the media, proper sleep affords a powerful and incredibly cost-effective mechanism to improve overall health. Studies such as this one provide evidence on the power of the bidirectional information exchange, the \u201cconversation,\u201d that is our gut-brain axis. Our gut microbiome, the driver of the gut\u2019s portion of the conversation \u2013 one\u2019s gut feelings, as it were \u2013 is highly dependent upon what we choose to eat. This singular fact gives us great control as to the direction and outcome of this particular t\u00eate-\u00e0-t\u00eate. With that control for health and healing within our hands, like Metallica, \u201cWe&#8217;re off to never-never land\u2026.\u201d<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"#_ftnref1\" id=\"_ftn1\">[1]<\/a> (Matenchuk , 2020)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">The Study: <a href=\"https:\/\/gpsych.bmj.com\/content\/38\/4\/e101855\">Shangyun Shi, Dongming Liu, Ancha Baranova, Hongbao Cao, Fuquan Zhang &#8211; Investigating bidirectional causal relationships between gut microbiota and insomnia: General Psychiatry 2025;38:e101855.<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Additional references:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"http:\/\/dx.doi.org\/10.1016\/j.jad.2011.01.011\">Baglioni C, Battagliese G, Feige B, <em>et al<\/em>. Insomnia as a predictor of depression: a meta-analytic<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"http:\/\/dx.doi.org\/10.1016\/j.jad.2011.01.011\">evaluation of longitudinal epidemiological studies. <em>J Affect Disord <\/em>2011;135:10\u20139.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"http:\/\/dx.doi.org\/10.1016\/j.bbi.2005.06.007\">Burgos I, Richter L, Klein T, <em>et al<\/em>. Increased nocturnal interleukin-6 excretion in patients with primary insomnia: a pilot study. <em>Brain Behav Immun <\/em>2006;20:246\u201353<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"http:\/\/dx.doi.org\/10.1053\/j.gastro.2020.10.066\">Margolis KG, Cryan JF, Mayer EA. The microbiota-gut-brain axis: from motility to mood. <em>Gastroenterology <\/em>2021;160:1486\u2013501.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"http:\/\/dx.doi.org\/10.1016\/j.smrv.2020.101340\">Matenchuk BA, Mandhane PJ, Kozyrskyj AL. Sleep, circadian rhythm, and gut microbiota. <em>Sleep Med Rev <\/em>2020;53:101340.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"http:\/\/dx.doi.org\/10.1056\/NEJMcp2305655\">Morin CM, Buysse DJ. Management of insomnia. <em>N Engl J Med. <\/em>2024;391:247\u201358.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"http:\/\/dx.doi.org\/10.1016\/j.smrv.2022.101691\">Wang Z, Wang Z, Lu T, <em>et al<\/em>. The microbiota-gut-brain axis in sleep disorders. <em>Sleep Med Rev <\/em>2022;65:101691.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cHush little baby, don&#8217;t say a word And never mind that noise you heard It&#8217;s just the beasts under your bed In your closet, in your head\u2026\u201d \u2014 Metallica, Enter&hellip;<\/p>","protected":false},"author":56,"featured_media":19711,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[11374,11367,11368,11372,11371,191,11726],"tags":[11710,183,11450,11622,11623,11720,195,221,11788,192,200,305,11576],"class_list":["post-19709","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-culinary-medicine-and-culinary-nutrition","category-food-as-treatment-for-disease","category-food-for-preventive-care","category-food-in-traditional-medicine","category-foods-and-ingredients","category-healthy-living","category-news-and-research-digest","tag-brain-gut-axis","tag-diet","tag-diet-related-disease","tag-gut-health","tag-gut-microbiome","tag-gut-microbiota","tag-health","tag-healthy-eating","tag-insomnia","tag-nutrition","tag-sleep","tag-sleep-habits","tag-study-spotlight"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.9 (Yoast SEO v27.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Insomnia and Gut Microbiome: Understanding the Link &#8212;<\/title>\n<meta name=\"description\" content=\"Explore the connection between insomnia and gut microbiome. 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